A Randomized Controlled Trial Comparing Mirabegron and Tamsulosin for Ureteral Stone Expulsion and Clinical Symptom Improvement

What this Trial Is About

Researchers are evaluating four different treatment strategies to help people with ureteral stones pass them more easily. This trial compares Mirabegron alone, Tamsulosin alone, their combination, and standard conservative care. The main goal is to see which treatment leads to the highest rate of stone expulsion within four weeks, while also looking at pain levels, use of pain relief medicine, fatigue symptoms, and possible side effects like palpitations or blood pressure changes. Participants will be randomly assigned to one of four groups: one taking Mirabegron 50 mg daily, another taking Tamsulosin 0.4 mg daily, a third group taking both medications daily, and a fourth group receiving standard care with pain control through NSAIDs or other analgesics as needed. Treatment lasts up to four weeks, during which symptoms and safety are monitored closely. During the study, participants will have their stone expulsion status checked along with assessments of pain intensity using a visual scale, fatigue symptoms, and total pain medication taken. Researchers will also record any adverse events throughout the treatment period. The study helps provide options for managing ureteral stones using medical expulsive therapy over a one-month period.

Comparison of Mirabegron and Tamsulosin for Ureteral Stone Expulsion