Comparison Of Percutaneous Mechanical Thrombectomy With Different Access in Treatment of Acute Deep Venous Thrombosis (The CODA Study)

What this Trial Is About

This research aims to compare different methods of performing percutaneous mechanical thrombectomy (PMT) for patients with acute iliofemoral deep venous thrombosis (DVT). It focuses on whether a modified approach using ipsilateral deep calf venous access or contralateral femoral venous access can achieve similar results as the traditional approach through ipsilateral popliteal venous access, especially in cases with distal popliteal vein thrombosis. The goal is to gather strong evidence to improve endovascular treatment for acute DVT and reduce post-thrombotic syndrome (PTS). The study involves three groups of patients with iliofemoral DVT: those with distal popliteal vein thrombosis treated by PMT via modified access routes (ipsilateral calf or contralateral femoral veins), those with distal popliteal vein thrombosis treated by the traditional ipsilateral popliteal venous access, and those without distal popliteal vein thrombosis treated by PMT via any access. During PMT, catheters and guide wires are used to remove the thrombus, with catheter-directed thrombolysis applied if residual clots remain, and balloon angioplasty and stenting performed if significant vein narrowing is detected. Participants will undergo imaging through venography before and after treatment to assess thrombus removal and vein patency. Researchers will monitor outcomes such as the incidence of post-thrombotic syndrome over 12 and 24 months, the success rate of thrombolysis, procedure duration, urokinase dosage, re-intervention rate, and long-term vein openness. The total follow-up period extends to 24 months to evaluate safety and effectiveness of the different PMT approaches.

Comparison Of Percutaneous Mechanical Thrombectomy With Different Access in Treatment of Acute Deep Venous Thrombosis