Actively Recruiting
Evaluation of Compression Ultrasound by Emergency Physicians to Exclude Proximal Deep Vein Thrombosis in Patients With Low Clinical Probability
Led by University Hospital, Strasbourg, France · Updated on 2025-08-03
700
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of compression ultrasound performed by emergency physicians to exclude the diagnosis of proximal deep vein thrombosis (DVT) in patients with a low clinical probability of having DVT. The study aims to compare the accuracy of compression ultrasound to the D-Dimer assay, which is considered the gold standard, especially for patients with non-high clinical pretest probability. This investigation is sponsored by University Hospital, Strasbourg, France. Participants with clinical suspicion of DVT and a non-high probability score based on the modified Wells criteria will undergo compression ultrasound during their emergency department visit. The ultrasound will be performed as standard care to assess its predictive value in ruling out DVT. If the D-Dimer test is positive, a follow-up whole leg Doppler ultrasound will be done within 5 days. Throughout the study, researchers will monitor the negative predictive value of compression ultrasound to confirm the absence of DVT either during the emergency stay or within the 5-day follow-up for those with positive D-Dimer results. Participants will provide informed consent and be assessed for eligibility based on clinical criteria. The total study duration extends until February 2027, with continuous evaluation of ultrasound accuracy and safety in this setting.
CONDITIONS
Brief Title
Compression Ultrasonography in Non-high Probability of Deep Vein Thrombosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient
- Patient presenting to the emergency department with clinical suspicion of deep vein thrombosis (pain and/or lower extremity swelling)
- Non-high probability for DVT based on modified Wells score (score of 0 or 1)
- Has social health insurance
- Able to understand study objectives and risks and provide signed informed consent
You will not qualify if you...
- Suspected pulmonary embolism
- High clinical probability of deep vein thrombosis
- Unable to perform whole leg Doppler ultrasound within 5 days
- Pregnant or breastfeeding woman
- Under court protection
- Under guardianship or curatorship
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - During emergency department stay or up to 5 days if initial assessment is positive
Participants undergo compression ultrasound performed by emergency physicians to evaluate for deep vein thrombosis.
1 visit during emergency department stay, with possible follow-up within 5 days
Trial Site Locations
Total: 1 location
1
CHU Strasbourg
Strasbourg, France
Actively Recruiting
Research Team
P
Pierrick LE BORGNE, MD
M
Mathieu OBERLIN, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here