Actively Recruiting
Led by Gazi University · Updated on 2026-02-03
30
Participants Needed
1
Research Sites
14 weeks
Total Duration
Coronary artery disease (CAD) causes reduced blood flow to the heart muscle, leading to symptoms like chest pain, breathlessness, and tiredness. Patients often avoid physical activity due to fear of chest pain, which lowers their exercise capacity. This study aims to compare the exercise abilities and arterial stiffness during exercise tests involving both the upper and lower limbs in people with CAD. It also evaluates muscle oxygen levels, energy use, and feelings of breathlessness and fatigue during these tests. Participants undergo two main exercise tests. The first test measures the maximal exercise capacity of the lower limbs using a treadmill while monitoring muscle oxygenation and energy use. Arterial stiffness and respiratory muscle fatigue are measured before and after this test. The second test, performed 48 hours later, measures the maximal exercise capacity of the upper limbs using an arm ergometer with similar monitoring and pre- and post-test evaluations. During the study, participants will have ongoing assessments of their exercise capacities, arterial stiffness, muscle oxygenation, respiratory muscle fatigue, energy consumption, and perceptions of breathlessness and fatigue. These measurements will be tracked for about one year. The study helps understand differences between upper and lower limb exercise in CAD patients and may provide insights for tailored exercise programs.
CONDITIONS
Comparison of Upper and Lower Limb Maximal Exercise Capacities and Arterial Stiffness in Patients With CAD
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 days
Participants undergo two cardiopulmonary exercise tests to evaluate maximal exercise capacities of the lower and upper extremities, arterial stiffness, muscle oxygenation, energy consumption, respiratory muscle fatigue, and perceptions of dyspnea and fatigue.
2 visits (in-person) spaced 48 hours apart
Duration - Up to 1 year
Participants are observed for outcomes including exercise capacity, arterial stiffness, muscle oxygenation, energy consumption, muscle strength, pulmonary function, physical activity level, chronotropic response, and perceptions of dyspnea and fatigue over approximately 1 year.
Visit schedule not specified
Total: 1 location
1
Gazi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Cardiopulmonary Rehabilitation Unit, Ankara, Çankaya 06490
Ankara, Çankaya, Turkey (Türkiye), 06490
Actively Recruiting
M
Meral BOŞNAK GÜÇLÜ, Prof. Dr.
N
Naciye SEVİM, Pt.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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