Aging

Researchers are evaluating whether the video-based exercise program Bliib fit - mach mit can improve physical fitness in older adults living in residential care facilities. The study aims to see if this program enhances physical fitness, quality of life, perceived fall risk, self-efficacy, and daily physical activity levels. This trial compares the video-based program to a caregiver-led activation program as an optimized standard care approach. Participants will take part in either the video-based exercise program or the caregiver-led activation program for 12 weeks. Each participant will engage in sessions four times a week, with each session lasting about 20 minutes. The video-based program focuses on mobilization, muscle strengthening, coordination, balance, and relaxation, supervised by a care professional. The caregiver-led activation program is instructed and carried out by care professionals individually or in groups. During the study, researchers will assess participants at baseline, after 12 weeks of intervention, and again 12 weeks after the intervention ends. They will measure physical fitness through tests like the Short Physical Performance Battery, grip strength, and a 2-minute walking test. Secondary measures include health-related quality of life, falls efficacy, self-efficacy, and physical activity tracked with accelerometers. This comprehensive monitoring aims to understand how the programs affect participants over time.

Eye disease affects billions worldwide, causing vision problems that impact daily life and productivity. This research focuses on eye health in coastal Bangladesh, a region with high poverty, limited healthcare access, and environmental risks that increase eye disease prevalence. The study evaluates a community-based eye screening program using Artificial Intelligence AI to detect conditions like diabetic retinopathy, glaucoma, cataracts, and age-related macular degeneration, aiming to improve early diagnosis and care in underserved areas. The program offers a twelve-step eye screening process supported by AI-assisted fundus imaging, combined with partnerships among local organizations and healthcare providers. Screening includes community outreach, vision tests, blood pressure and glucose checks, optometrist evaluations, and selective AI imaging for higher-risk individuals based on age, diabetes, hypertension, or symptoms. Patients diagnosed with severe cataracts are offered surgery through local or regional services. The approach integrates data collection, AI analysis, clinical examinations, counseling, and referrals to support comprehensive eye care. Participants aged 35 and older from the Char Fasson sub-district undergo screening and follow-up over several months. The study collects demographic, clinical, and imaging data securely, with informed consent for storing fundus images. Researchers monitor the number of individuals screened and the prevalence of eye diseases. Safety and data privacy are maintained using encrypted systems and compliance with ethical standards. The programs feasibility, cost, and effectiveness in improving eye care accessibility are assessed throughout the study.

Researchers are evaluating the AGIL Barcelona program to help frail older adults improve their physical abilities and delay disability. This study focuses on adapting and expanding the program across different community health centers in Barcelona. It aims to measure improvements in physical performance using a simple test SPPB and assess how well the program can be implemented in various neighborhoods. The program includes up to 10 weekly group exercise sessions led by a physiotherapist, emphasizing strength, balance, flexibility, and endurance. Participants receive personalized exercises supported by easy-to-understand materials. The program also offers advice on healthy habits like the Mediterranean diet, sleep improvement, and managing swallowing or memory issues. Medication reviews are conducted to ensure safe and appropriate treatments, and support is provided to connect participants with local activities to reduce social isolation. Participants will be involved in assessments of their physical performance, quality of life, cognitive function, social engagement, diet adherence, medication use, and any adverse events at the start, three months, and six months. The study uses a stepped approach to introduce the program at different sites gradually. Researchers will also gather qualitative feedback on participants experiences and program implementation. The total participation duration includes baseline and follow-up visits over six months.

The 100-Year Human Aging Study is a long-term observational research project enrolling adult participants to undergo detailed multi-system health screenings and follow them throughout their lives until death. The study aims to identify which health measurements taken at enrollment and repeatedly over time can predict overall mortality, cause-specific death, serious diseases, and functional disability. It addresses the current lack of validated longevity measures by generating data on how various physiological and cognitive functions relate to aging outcomes. Participants undergo a comprehensive clinical screening that includes tests of cardiorespiratory fitness, strength, mobility, neurocognitive performance, sensory functions, and metabolic health. Structural imaging assessments like DEXA scans, echocardiography, electrocardiography, spirometry, retinal photography, and vascular ultrasound are performed. Laboratory tests and detailed medical, social, and environmental histories are also collected. The study allows participation from single tests up to a full two-visit screening, with repeat testing encouraged to track health changes over time. Throughout the study, participants receive individualized reports with investigational estimates of biological age and predicted mortality risks, which are being evaluated against actual health outcomes. Researchers collect data continuously on mortality, disease occurrence, disability, and health behavior changes. The study involves ongoing follow-up with periodic assessments and aims to preserve all collected data for future analyses, with participant involvement potentially spanning their entire lifespan.

Researchers are studying the use of a 2,910 nm mid-infrared Fiber Laser UltraClear, Acclaro Medical to treat advanced perioral lines and wrinkles. The goal is to assess the lasers effectiveness for skin rejuvenation by using both superficial epidermis ablation and deeper skin layers ablative and coagulative effects. The study also aims to evaluate safety and participant satisfaction with this resurfacing treatment for photodamaged skin and wrinkles. Participants will receive up to two treatments with the UltraClear laser, spaced 6 to 8 weeks apart. These treatments focus on improving the appearance of perioral lines and wrinkles using the lasers combined superficial and deep skin effects. Following treatments, participants will have follow-up visits at 1 month and 3 months to evaluate the results and any side effects. Throughout the study, researchers will measure improvements using multiple scales, including the Fitzpatrick Wrinkling and Degree of Elastosis Scale, Physician Global Aesthetic Improvement Scale, and assessments by independent photographic reviewers. Participants will also report their own perceptions of aesthetic improvement and satisfaction. Safety and overall aesthetic outcomes will be monitored during follow-ups, with the total participation lasting through the 3 months after the final treatment.

This research aims to compare surgical outcomes and parameters between cataract surgeries performed using a new 3D imaging system called the NGENUITY4 3D Visualization System and the current standard binocular microscope in patients with high myopia. The study focuses on how differences in depth of field between these two systems affect factors during surgery and the results, including potential complications. Participants will have high myopia and significant cataracts requiring surgery. Participants will be randomly assigned to one of two groups one group will undergo cataract surgery using the standard binocular microscope, while the other group will have surgery using the Alcon NGENUITY4 3D Visualization System. During surgery with the NGENUITY system, the surgeon wears 3D glasses and views the operation on a 3D screen. Both groups receive standard cataract extraction with phacoemulsification and intraocular lens implantation. Throughout the surgery, researchers will measure how often and how far the microscope focus is adjusted, the distance needed to focus from the corneal surface to the lens capsule, total operation time, and ultrasound energy used. After surgery, participants will be followed for three months to monitor vision, eye pressure, and any complications. These assessments will occur on day 1, week 1, month 1, and month 3 after surgery to evaluate safety and effectiveness of the two visualization methods.

Researchers are evaluating how a combined program of aerobic and resistance exercises along with cognitive training affects brain function in older adults aged 60 and above. The study focuses on people who are sedentary and may or may not have cardiovascular risk factors like diabetes, high blood pressure, or high cholesterol, conditions known to impact memory and attention. This trial aims to compare the effects of physical exercise alone versus combined physical and cognitive training on thinking skills and brain health. The trial includes three groups one group will do both cognitive and physical training, another will do only aerobic and resistance exercises, and the third group will perform stretching and toning exercises as an active control. Each group participates in three sessions per week for 46 weeks, with options to train at home or at a center. The physical exercise sessions include warm-up, moderate to vigorous aerobic activity monitored by heart rate, and resistance training, while cognitive training involves computer-based memory and attention tasks. Participants will undergo assessments at the start and after 12 months to measure changes in general cognition, processing speed, executive functions, and memory. Brain imaging and blood flow measures will also be evaluated to observe changes in brain structure and function. Throughout the study, participants will be monitored for exercise intensity and adherence. The total study duration covers 12 months, with safety and cognitive outcomes closely tracked to understand the impact of these interventions.

Researchers are evaluating a computer-based cognitive rehabilitation program called Enhancing Memory in Daily Life E-MinD Life aimed at delaying functional decline related to cognitive changes in Chinese healthy older adults, those with memory complaints, mild cognitive impairment MCI, and mild dementia. This pilot study is conducted in Hong Kong and includes participants without depression or other clinical conditions affecting cognition. The study uses a randomized controlled design to assess the feasibility and benefits of the E-MinD Life program. The trial has two groups one receives the E-MinD Life Semantic program, which teaches memory strategies applied to 12 daily activities over 9 weeks with weekly sessions led by healthcare professionals and family-assisted home practice. The other group receives cognitive stimulation through visual and auditory memory activities with a similar schedule. Both interventions include one 45-minute individual session and two 30-minute home sessions weekly. Participants will attend sessions either face-to-face or online, with family or carers involved for support and observation. Researchers will assess acceptability at the end of the 9-week intervention and measure feasibility through attendance rates. Cognitive and daily living abilities will be evaluated using various tests from enrollment to intervention end. The total participation includes these assessments and intervention monitoring over 9 weeks.

Researchers are evaluating the use of a high protein egg white pudding as a nutritional supplement for people with kidney failure who are on dialysis. The study aims to find out if giving this egg white pudding after dialysis is practical and whether it can improve blood protein levels, frailty, dietary intake, and other blood markers compared to a standard supplement called Ensure Plus. This trial is conducted by Seven Oaks Hospital Chronic Disease Innovation Centre. Participants will be randomly assigned to receive either the egg white protein pudding or Ensure Plus at the end of their dialysis treatments three times a week for 12 weeks. Both supplements are dietary and taken during the dialysis sessions. The study collects data during this 12-week intervention period to evaluate the effects of the two supplements. During the study, participants will be monitored for their ability to stay in the trial, adherence to the supplements, and health measures such as hand grip strength, walking speed, balance, and blood levels including serum albumin and electrolytes. These assessments occur at the end of the 12 weeks. The trial also tracks recruitment and follow-up rates to evaluate feasibility. Overall, participants are involved in regular supplement intake and health testing during dialysis over three months.

Researchers are evaluating the effects of Promoting Healthy Aging with Sport Exercise PHASE Programs on the functional abilities of older adults. This study aims to match sport exercises to older adults at different stages of their physical and mental health to promote healthy aging. The evaluation includes overall health, physical, psychological, and cognitive functions measured at baseline, 3 months, and 6 months after intervention. Participants will be assigned to one of six groups five different tailored exercise programs and one control group with no exercise. The exercise interventions include football training, gerotechnology-enhanced multi-component exercises, slow sports and exercises, walking exercises, and home-based training. The gerotechnology program consists of 8 weekly sessions of musculoskeletal, neuromuscular, and cardiometabolic training. Slow sports offer up to 10 sessions including activities like Tai Chi and Yoga. Football training involves multiple stages with sessions and game days. Home-based training includes four personal sessions over four weeks. Participants will be assessed at the start, 3 months, and 6 months after the interventions. Evaluations include self-rated health, mobility, activity levels, functional mobility, sarcopenia risk, hand grip strength, loneliness, and cognitive function. Exercise intensity is also monitored for each participant. The study is designed to explore the benefits of tailored exercise programs on aging over a period of 6 months post-intervention.