Actively Recruiting
Effects of 12-week Magnesium Supplementation on Peri-menopause Symptoms, Cognition, Sleep and Psychological Wellbeing - a Randomised, Placebo-controlled Trial
Led by Northumbria University · Updated on 2026-05-29
58
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
Northumbria University
Lead Sponsor
V
Vitabiotics
Collaborating Sponsor
AI-Summary
What this Trial Is About
Perimenopause is the phase before menopause where women experience symptoms like hot flushes, night sweats, mood swings, anxiety, sleep problems, fatigue, and trouble with memory or concentration. These symptoms can be frequent and intense, affecting quality of life. Despite growing awareness, there is limited research on how diet and supplements impact menopause symptoms. This study investigates the effects of 12 weeks of magnesium supplementation on symptoms, cognition, sleep, and psychological well-being in perimenopausal women. The study compares two groups: one taking a magnesium hydroxide supplement and the other a placebo, both for 12 weeks. Each participant will take two capsules daily of either magnesium hydroxide or placebo. The trial is randomized and triple-blinded to fairly assess the effects of magnesium. The treatment period lasts 84 days with assessments conducted at baseline, 6 weeks, and 12 weeks. Participants will complete memory and cognitive tasks, such as numeric and alphabetic working memory tests, recognition tasks, and the Corsi blocks task, at three time points. They will also fill out questionnaires measuring menopause-specific quality of life, depression, anxiety, stress, mood, and sleep quality. These measures will help researchers understand how magnesium may influence cognition, psychological health, and sleep during perimenopause. The study is led by Northumbria University and plans to end in August 2026.
CONDITIONS
Brief Title
12-week Magnesium Supplementation on Peri-menopause Symptoms, Cognition, Sleep, and Psychological Well-being
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Self-assess as healthy
- Report experiencing troublesome peri-menopause symptoms in the past 6 months
- Not post-menopausal (defined as 12 months with no periods)
- Female
- Aged between 40 and 60 years
You will not qualify if you...
- Post-menopausal
- Lactating, pregnant or seeking to become pregnant
- Nut allergy
- Taken antidepressant or antianxiety medication, or other medication likely to affect cognition or sleep in the past 6 months
- Habitual magnesium supplementation (more than 3 consecutive days or 4 days in total) without a 1-month washout
- Menopause symptoms medically induced
- Receiving gender-affirming hormone therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants take either magnesium hydroxide or placebo capsules daily for 12 weeks to assess effects on peri-menopause symptoms, cognition, sleep, and psychological well-being.
3 visits (at baseline, 6 weeks, and 12 weeks)
Trial Site Locations
Total: 1 location
1
School of Psychology, Northumbria University
Newcastle upon Tyne, United Kingdom, NE1 8ST
Actively Recruiting
Research Team
C
Crystal Haskell-Ramsay
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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