Cartilage Injury

This research aims to compare two surgical methods for treating hip labral tears, a condition affecting the cartilage around the hip joint. The study focuses on patients with femoroacetabular impingement and traumatic labral tears to evaluate which treatment may lead to better hip function and pain relief. The trial is a randomized, double-blind comparison conducted by Ain Shams University. Participants will undergo hip arthroscopy under general anesthesia, where surgeons will use two portals to access the hip joint under fluoroscopic guidance. Patients will be randomly assigned to receive either arthroscopic labral repair, which uses suture anchors to fix the tear, or arthroscopic labral debridement, which involves removing damaged tissue using electrocautery. Both procedures address any labral, cartilage, or bony issues present during surgery. Participants' hip function and pain levels will be assessed before surgery and at 1, 3, and 6 months, as well as at 1 year after the procedure, using the Hip Outcome Score, Harris Hip Score, and Visual Analog Scale. These evaluations will help measure changes in hip function and pain over time. The study follows patients for a total of one year after surgery to monitor recovery and outcomes.

Researchers are evaluating the effectiveness and safety of MACI compared to arthroscopic microfracture for treating young patients aged 10 to 17 years who have symptomatic cartilage or osteochondral defects in the knee. This phase 3 clinical trial seeks to understand which treatment better improves pain and function related to these knee defects. This study randomly assigns a total of 45 patients into two groups: 30 will receive a single treatment with MACI, which involves autologous cultured chondrocytes on a porcine collagen membrane, and 15 will receive arthroscopic microfracture treatment during a screening arthroscopy. Patients assigned to MACI return within 12 weeks for the cell implantation surgery and follow a recommended rehabilitation program. The trial lasts for two years after treatment to monitor outcomes. Participants undergo a screening arthroscopy to confirm eligibility and have a cartilage biopsy taken before treatment. Researchers will monitor cartilage lesion size, compliance with rehabilitation, and measure improvements in knee pain and function using KOOS-Child scores over 104 weeks. Safety and efficacy are tracked carefully throughout the study period.

Researchers are evaluating the safety and effectiveness of MACI, which involves autologous cultured chondrocytes on a porcine collagen membrane, compared to Bone Marrow Stimulation for treating patients aged 17 to 65 with symptomatic cartilage or bone defects in the ankle. This phase 3, open-label clinical trial aims to demonstrate whether MACI is superior to Bone Marrow Stimulation in improving ankle function and pain over two years. The study enrolls about 309 participants randomly assigned in a 2:1 ratio to receive either MACI or Bone Marrow Stimulation. Eligible participants must have at least one cartilage lesion of 1.2 cm² or larger on the talus. After initial screening and ankle arthroscopy, a cartilage biopsy is taken. Those assigned to MACI undergo implantation surgery 5 to 12 weeks later, while those in the Bone Marrow Stimulation group receive treatment during arthroscopy. Both groups follow recommended rehabilitation programs. Participants will have follow-up visits to assess safety at weeks 6 and 12, and for both safety and efficacy at weeks 24, 36, 52, 78, and 104 after treatment. Researchers will monitor pain, function, symptoms, daily living ability, and quality of life using the FAOS questionnaire. Rehabilitation progress is tracked through the first year. The total study period for each participant spans two years from treatment to final assessments.

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or Weil/Hohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing (10-15 kg) during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery: one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

Researchers are evaluating absorbable sutures compared to non-absorbable sutures used for capsular repair during hip arthroscopic procedures. This study aims to assess how these suture types affect hip function and recovery in patients with hip joint injuries such as labrum injury, femoroacetabular impingement syndrome, and those undergoing hip arthroscopy. Major outcomes will be measured with patient questionnaires and radiographic imaging to monitor healing and complications. The study involves two groups receiving either absorbable or non-absorbable sutures for hip capsular closure during surgery. Participants will complete several questionnaires including the International Hip Outcome Tool-12, modified Harris hip score, and hip outcome score, as well as nine standard care questionnaires at multiple time points: before surgery, and at 6 weeks, 3 months, 6 months, 1 year, 2 years, and any other follow-up visits. Radiographs taken as part of standard care will be used to evaluate heterotrophic ossification at 6 months after surgery. Participants will be monitored through surveys assessing hip function, pain, activity, and surgical satisfaction, along with radiographic imaging at follow-up visits. The main outcomes measure changes in hip-related quality of life and function up to 12 months post-surgery. Safety and healing will be monitored through imaging at 6 months. The total participation duration may extend to 2 years or more, depending on follow-up visits.

This research aims to compare two surgical treatments for people aged 18 to 55 years undergoing primary hip arthroscopy due to a focal cartilage defect in the acetabulum. It is a pilot randomized controlled trial assessing the effects of autologous matrix-induced chondrogenesis (AMIC) versus microfracture on hip function, quality of life, pain, cartilage repair, and health utility over two years. The study follows participants for 24 months with scheduled check-ins at 6 weeks, 6 months, 12 months, 18 months, and 24 months after surgery. During surgery, all participants will have unstable cartilage removed and microfracture performed by making small holes in the bone to encourage healing. Those in the AMIC group will also receive a collagen matrix implant placed over the cartilage defect to support tissue repair. This matrix is secured precisely and checked arthroscopically to ensure proper placement. Both treatments are done during the same surgical procedure. Participants will attend follow-up visits at set intervals over two years to assess their hip function using the International Hip Outcome Tool (iHOT-33) and other measures such as pain, cartilage repair via MRI scoring, health status, and any adverse events. Researchers will monitor changes from before surgery to 24 months afterward to evaluate the treatments' effects. The trial is led by McMaster University and includes detailed assessments to understand outcomes and safety.

Osteoarthritis is a common degenerative condition that affects the knee joint, causing pain and reduced function that worsens over time. It impacts both older and younger adults, sometimes due to injury. This research aims to better understand osteoarthritis onset and progression by improving diagnostic and prognostic methods, as current treatments mainly focus on managing symptoms rather than addressing underlying causes. The study evaluates the use of Magnetic Resonance Imaging (MRI) and gait analysis to examine the knee joint's condition and function. MRI will provide detailed images of joint tissues, while gait analysis, combined with sensor data and musculoskeletal models, will assess joint forces and movements during walking. These diagnostic tests will be conducted at the start of the study and again after 12 months to observe any changes. Participants will undergo MRI scans, strength tests using a manual dynamometer, bioimpedance analysis, gait analysis including electromyography, and complete clinical questionnaires at both baseline and 12-month follow-up visits. Researchers will monitor these assessments to understand joint health and function over time. The study does not involve any treatment but focuses on diagnostic evaluation, lasting at least one year for each participant.

Researchers are evaluating the effectiveness and safety of autologous costal osteochondral transplantation compared with autologous osteoperiosteal transplantation in treating Hepple Stage V talar osteochondral lesions. The main goal is to determine if the costal osteochondral transplantation can provide better clinical outcomes and improved cartilage repair with fewer donor site complications than the osteoperiosteal transplantation. Participants will be randomly assigned to one of these two surgical treatments. The study involves two treatment groups: one receiving the autologous costal osteochondral transplantation, which includes harvesting an osteochondral column from the rib and implanting it into the talar defect, and the other receiving autologous iliac osteoperiosteal transplantation, which involves obtaining a cylindrical osteoperiosteal column from the iliac crest for implantation. Both surgeries include removing the talar lesion, filling the cavity with cancellous bone, and ensuring the transplant surface aligns with the surrounding cartilage. After surgery, all participants will follow the same rehabilitation and follow-up plan. Participants will be monitored over time with various assessments including the American Orthopedic Foot and Ankle Society (AOFAS) ankle-hindfoot scale at multiple intervals up to 24 months after surgery. Additional measures include pain ratings during walking, cartilage repair evaluations by MRI, functional scores, bone healing, patient satisfaction, and monitoring for any complications. The study aims to collect detailed data on clinical outcomes and safety over two years following the surgical treatment.

Researchers are conducting a multicenter prospective cohort study to evaluate the clinical results and safety of autologous osteoperiosteal transplantation in patients with severe osteochondral lesions of the talus (OLT). The study aims to determine whether this procedure provides good clinical outcomes and fewer postoperative complications when treating severe OLT. This study is sponsored by Peking University Third Hospital. Participants will undergo autologous osteoperiosteal transplantation, where a bone graft is taken from the iliac crest and transplanted to repair the lesion in the talus. The surgical procedure involves drilling and debriding the cystic lesion before grafting bone tissue. The study includes clinical follow-up visits at 3, 6, 12, and 24 months after surgery, with imaging examinations such as CT and MRI performed before surgery and at 12 and 24 months post-operation. During the study, participants will complete ankle function assessments including the Foot and Ankle Outcome Score (FAOS) at multiple time points up to 24 months after surgery. Additional measures include the American Orthopedic Foot and Ankle Society Score, Visual Analogue Scale for pain, Ankle Activity Score, and cartilage repair imaging assessments. Complications will be monitored up to 48 months after surgery to evaluate safety and donor-site morbidity. Participants will be closely followed to assess recovery and clinical outcomes over this period.

Researchers are evaluating the safety and effectiveness of the BioPoly4 Partial Resurfacing Knee Implant for treating cartilage defects in the distal femur of adults with knee pain who need surgical intervention. This clinical trial compares outcomes of the BioPoly device to standard surgical care, which includes microfracture or debridement procedures, in patients with specific cartilage lesions. The study aims to demonstrate improved knee function and reduced need for additional surgeries over 24 months. Participants will be randomly assigned to receive either the BioPoly Knee device or the standard surgical care. The BioPoly device is designed to replace damaged cartilage in the femoral condyles or trochlear facets in patients aged 30 to 65 with certain lesion characteristics. The control group will undergo microfracture or debridement based on factors like age, lesion size, and osteoarthritis severity. Treatments are surgical and early interventions before joint replacement. During the 24-month study, participants will be monitored for knee function using the Knee injury and Osteoarthritis Outcome Score (KOOS) and checked for the need for secondary surgeries. Safety will be assessed by tracking adverse events and implant stability through radiographs. Researchers will measure pain reduction and overall treatment success, with follow-up visits including clinical assessments and imaging to evaluate outcomes and implant survival.