Study of Estradiol Patch Effects on Hormone Response in Pre-Menopausal Women with Normal and High BMI

What this Trial Is About

Researchers are studying pre-menopausal women aged 18 to 40 years with regular menstrual cycles to understand how obesity affects hormonal responses related to fertility. The focus is on whether obesity leads to a reduced luteinizing hormone surge triggered by estradiol at the pituitary and hypothalamus level. This study aims to compare these hormonal changes between women with normal and high body mass index BMI. Participants will wear estradiol patches for 7 days during the treatment period. There are two groups normal weight women and women with a BMI greater than 30. Both groups will apply the transdermal estradiol patch and collect daily morning urine samples to measure the luteinizing hormone surge. Blood will be drawn on day 3 of patch use to monitor hormone levels. The study includes a screening period lasting up to 3 weeks before treatment. During the study, participants will undergo hormone level assessments through blood draws and urine collection. They must use reliable barrier contraception or abstain from intercourse throughout the trial. Researchers will measure the amount and timing of the luteinizing hormone surge over the 7-day treatment. The total participation time includes screening and treatment phases, with safety monitored through hormone and health assessments.

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women