Actively Recruiting
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women
Led by University of Colorado, Denver · Updated on 2025-05-01
20
Participants Needed
2
Research Sites
92 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
C
Colorado Clinical & Translational Sciences Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.
CONDITIONS
Official Title
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-38
- Regular menstrual cycles every 25-35 days
- No use of reproductive hormones within the past 3 months
- No use of medications interacting with reproductive hormones
- Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
- Normal thyroid stimulating hormone, prolactin and lipid profiles
- No more than 4 hours of moderate to vigorous intensity exercise per week
- No history of chronic disease impacting reproductive hormones
- No contraindications to administration of estradiol
- No history of estrogen dependent cancer
- Negative pregnancy test
You will not qualify if you...
- Has diabetes
- Is a smoker
- History of venous thromboembolism or known thrombophilia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Colorado School of Medicine
Aurora, Colorado, United States, 80045
Not Yet Recruiting
2
University of Colorado-School of Medicine
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
K
Katherine Kuhn
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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