Study of Vitamin D Levels and Lung Immune Cells in Adults with Idiopathic Pulmonary Fibrosis and Other Lung Diseases

What this Trial Is About

Researchers are studying the role of human macrophages and vitamin D in people with Idiopathic Pulmonary Fibrosis IPF. The study aims to understand whether patients with IPF have low vitamin D levels in their blood and lungs, and whether their lung macrophages promote fibrosis and inflammation. This observational research is sponsored by the University of Aarhus and focuses on gaining deeper insights into these factors in IPF and related lung diseases. Participants in this study include patients diagnosed with IPF, non-IPF interstitial lung disease, or lung cancer. There are no specific treatment interventions as this is an observational study. The study collects blood and bronchoalveolar lavage BAL samples to measure biomarker levels, vitamin D status, and analyze pulmonary macrophages at enrollment. During the study, participants undergo assessments at enrollment to evaluate vitamin D levels and lung macrophage characteristics. Blood and BAL samples are collected for biomarker analysis. The study seeks to better understand disease mechanisms by comparing these measures across different lung conditions. Participation involves providing informed consent and attending study visits for sample collection and assessments. The study started in October 2024 and will continue until October 2026.

D Vitamin and Alveolar Macrophages in Idiopathic Pulmonal Fibrosis