Terminology for describing normally sited and ectopic pregnancies on ultrasound: ESHRE recommendations for good practice.
ESHRE working group on Ectopic Pregnancy, Emma Kirk, Pim Ankum...
https://pubmed.ncbi.nlm.nih.gov/33354626Actively Recruiting
FEMALE
ID05969574
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study
Led by ART Fertility Clinics LLC · Updated on 2025-02-19
2059
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore the possible link between decreased ovarian reserve and the history of early miscarriages in women. The study focuses on populations with specific reproductive histories, including recurrent pregnancy loss, no previous pregnancies (G0), and ectopic pregnancies, to understand how low ovarian reserve (LOR) may affect fertility outcomes. The goal is to provide insights that could improve infertility treatments and help participants achieve their parenting goals. Participants in this observational study will undergo routine clinical assessments without additional interventions beyond standard testing. These tests include measuring anti-Müllerian hormone (AMH) levels and performing antral follicle counts (AFC) through transvaginal ultrasound on the day of their first consultation. Standard ovarian stimulation protocols and medications will be followed as per usual care. Throughout the study, researchers will monitor AMH and AFC as primary outcomes to evaluate ovarian reserve. Participants will receive regular clinical assessments and testing as part of their normal care. The study aims to provide valuable data on how LOR correlates with fertility outcomes, miscarriage history, and embryo aneuploidy rates, helping to guide future clinical decisions and reduce patient distress. The study is expected to continue until the end of 2025.
CONDITIONS
Brief Title
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
Who Can Participate
FEMALE
Eligibility Criteria
You may qualify if you...
- Female participants with at least one previous pregnancy
- Assessed at ART Fertility Clinics in Abu Dhabi, Al Ain, or Dubai
You will not qualify if you...
- Severe male infertility factors such as azoospermia or severe oligoasthenoteratozoospermia
- Severe endometriosis or adenomyosis diagnosed by history or ultrasound
- Uterine abnormalities including fibroids or uterine septum
- History of ovarian surgery, chemotherapy, or radiation therapy
- Known genetic disorder or chromosomal abnormality
- Body mass index (BMI) greater than 40 kg/m2
- Current use of hormonal contraception or hormone replacement therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo transvaginal ultrasound and blood test for AMH to assess ovarian reserve.
1 visit (in-person)
Long-term Monitoring
Duration - Duration of routine clinical assessment
Participants who undergo routine fertility care are observed to understand the impact of ovarian reserve on fertility outcomes.
visit frequency depends on routine clinical care
Trial Site Locations
Total: 3 locations
1
ART Fertility Clinics LLC
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates, 60202
Actively Recruiting
2
ART Fertility Clinics Al Ain
Al Ain City, United Arab Emirates
Actively Recruiting
3
ART Fertility Clinics Dubai
Dubai, United Arab Emirates
Actively Recruiting
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Research Team
B
Barbara Lawrenz, PhD
J
Jonalyn Edades, RN
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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Published Research Related To This Trial
Decreased Ovarian Reserves With an Increasing Number of Previous Early Miscarriages: A Retrospective Analysis.
Jifan Tan, Lu Luo, Jiaxin Jiang...
https://pubmed.ncbi.nlm.nih.gov/35757430Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss.
Sofie Bliddal, Ulla Feldt-Rasmussen, Julie Lyng Forman...
https://pubmed.ncbi.nlm.nih.gov/37055255Recurrent miscarriage. II: Clinical associations, causes, and management.
G M Stirrat
https://pubmed.ncbi.nlm.nih.gov/1975901Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study.
Xiaobin Wang, Changzhong Chen, Lihua Wang...
https://pubmed.ncbi.nlm.nih.gov/12620443Recurrent miscarriage: evidence to accelerate action.
Arri Coomarasamy, Rima K Dhillon-Smith, Argyro Papadopoulou...
https://pubmed.ncbi.nlm.nih.gov/33915096Diminished ovarian reserve in recurrent pregnancy loss: a systematic review and meta-analysis.
Sarah J Bunnewell, Emma R Honess, Amar M Karia...
https://pubmed.ncbi.nlm.nih.gov/32145928Connecting the dots between oocyte quantity and quality in diminished ovarian reserve.
David B Seifer
https://pubmed.ncbi.nlm.nih.gov/33750616Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer.
Bruno Tarasconi, Teddy Tadros, Jean-Marc Ayoubi...
https://pubmed.ncbi.nlm.nih.gov/28865551Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies.
Brianna M Lyttle Schumacher, Anne Marie Z Jukic, Anne Z Steiner
https://pubmed.ncbi.nlm.nih.gov/29871793