Using Stool and Urine Markers to Track Carbohydrate Intake in Adults with Irritable Bowel Syndrome A Randomized Controlled Study Comparing Elimination and Healthy Eating Diets

What this Trial Is About

Researchers are evaluating whether a specific marker found in stool or urine can track changes in carbohydrate intake, including fructo-oligosaccharide and mannitol intake, in adults with Irritable Bowel Syndrome IBS. The study aims to find an objective biomarker using Gluten Immunogenic Peptides GIP to assess carbohydrate consumption, which is important for managing dietary treatments in IBS. Participants will be randomly assigned to one of two diet groups. One group will follow an elimination diet limiting oligosaccharides intake, while the other will follow a healthy eating diet focusing on balanced meals, fluid intake, and reduced fatty or spicy foods. These dietary interventions will be studied over a four-week period to observe their effects on carbohydrate intake markers. During the study, participants will have their stool and urine analyzed to measure GIP levels and will complete dietary recalls and symptom questionnaires, including the Irritable Bowel Severity Scoring System and PROMIS abdominal pain and bloating scores. The primary outcome is the correlation between fecal GIP excretion and fructo-oligosaccharide intake at week 4. The total study duration is four weeks, with safety and symptom monitoring throughout.

Defining Objective Markers of Compliance for Dietary Therapies in IBS