Actively Recruiting
Measuring Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Led by Ali Chappell · Updated on 2026-05-01
150
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how fasting insulin and the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) vary by age, sex, race/ethnicity, BMI, and polycystic ovary syndrome (PCOS) diagnosis. This study focuses on understanding metabolic health and insulin regulation across diverse groups to better identify risks for insulin-related conditions. It highlights the importance of measuring insulin and HOMA-IR alongside glucose levels to gain deeper insights into metabolic dysfunction. This observational study enrolls adults 18 years and older from varied backgrounds, including those with and without PCOS. Participants must have completed recent metabolic tests such as fasting insulin, hemoglobin A1c, lipid panels, and triglycerides after fasting at least eight hours. Data will be collected cross-sectionally, and analyses will explore how these factors influence insulin sensitivity and resistance. Participants will provide recent laboratory results performed by healthcare providers, labs, or using a specific insulin testing kit. Researchers will assess insulin and HOMA-IR levels, examining their relationship with demographic and clinical characteristics. The main outcome is measuring fasting insulin and HOMA-IR scores over a three-year period. The study aims to improve understanding of metabolic health markers to support better diagnosis and prevention strategies.
CONDITIONS
Brief Title
Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 years or older
- Both males and females of all racial and ethnic backgrounds
- Participants with a range of body mass index (BMI) values
- Participants with or without a confirmed diagnosis of polycystic ovary syndrome (PCOS)
- Completion of metabolic testing within one month prior to enrollment, including fasting insulin, hemoglobin A1c, complete lipid panel, and triglycerides
- Laboratory testing performed by a healthcare provider, independent laboratory, or using an Insara Insulin Testing Kit
- Laboratory values obtained after a minimum 8-hour fast
- Complete laboratory data available for all required measures
You will not qualify if you...
- Participants younger than 18 years
- Presence of other endocrine disorders affecting insulin levels, such as insulin-secreting tumors
- Significant recent weight loss exceeding 5% of body weight within the previous month
- Pregnancy or breastfeeding
- Acute illness or infection within the past 2 weeks
- Use of medications known to significantly affect insulin or glucose metabolism (these will be recorded and considered in analysis)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - Up to 1 month
Participants undergo metabolic testing to measure fasting insulin, hemoglobin A1c, lipid panel, triglycerides, and calculate HOMA-IR to assess metabolic health.
1 visit (in-person or laboratory-based testing)
Duration - Up to 3 years
Participants' metabolic health data are observed and analyzed over time to study the influence of demographic and clinical factors on insulin sensitivity.
No scheduled visits; data collection occurs through existing records and laboratory results
Trial Site Locations
Total: 1 location
1
Lilli Health
Houston, Texas, United States, 77554
Actively Recruiting
Research Team
A
Ali M Chappell, PhD, MS, RD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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