Early Detection of Kidney Injury Using Biomarkers in Adults with Diabetes Undergoing Heart Artery Procedures

What this Trial Is About

This research focuses on patients with diabetes mellitus who have a higher risk of kidney failure after using dye during heart artery procedures like percutaneous coronary intervention PCI. Diabetes significantly increases the chance of developing contrast induced nephropathy CIN, which can raise mortality within one year. The study aims to find new biomarkers that detect CIN earlier than current methods, improving safety and outcomes for this high-risk group. The study observes diabetic patients with reduced kidney function eGFR <60 mlmin undergoing planned PCI. Blood and urine samples will be collected before the procedure, then at 2, 4, 8 to 12 hours, before discharge, and 3 days post-procedure. These samples will be analyzed to identify biomarkers that could predict CIN development within 72 hours after the procedure. Participants will follow their usual care during the hospital stay while providing additional blood and urine samples. Researchers will monitor creatinine levels and biomarker presence to assess kidney injury risk. The main outcome is defined as an increase in creatinine of 44 micromoll or more within 72 hours after PCI. This observational study includes about 250 patients and aims to improve early diagnosis and treatment of CIN in diabetic patients undergoing coronary revascularization.

Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes