Study on How Vitamin C and Ibuprofen Affect Muscle Recovery and the Repeated Bout Effect in Adults Aged 18 to 45

What this Trial Is About

Researchers are investigating how oxidative stress and inflammation affect the repeated bout effect RBE, which helps protect muscles from soreness and performance loss after eccentric exercise. The study focuses on whether taking vitamin C and ibuprofen, common supplements used to reduce these effects, influences the development of the RBE. This is a double-blind, placebo-controlled, randomized trial to better understand how these supplements impact muscle recovery after strenuous exercise. Participants will be assigned to one of two groups one group will receive 1,000 mg of vitamin C and 400 mg of a non-steroidal anti-inflammatory drug every 8 hours for 48 hours, while the other group will receive a placebo that looks identical. The study aims to mimic protocols reported to have beneficial effects on oxidative stress and inflammation. The intervention is compared to an identical maltodextrin placebo. During the study, muscle function will be measured at baseline, and then at 2 hours, 1 day, and 7 days after exercise. Researchers will also monitor muscle enzyme levels called creatine kinase at multiple points up to 48 hours post-exercise to assess muscle damage. Participants must be able to perform 20 minutes of bench stepping exercise and will be monitored for any inflammation or medication use. The total participation period covers multiple assessments to understand recovery and the repeated bout effect.

Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?