Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration.
R S Bar, P Gorden, J Roth...
https://pubmed.ncbi.nlm.nih.gov/194912/Actively Recruiting
Led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Updated on 2026-07-23
1500
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to understand the causes and treatment of fasting hypoglycemia, including conditions like insulinomas and other pancreatic neuroendocrine tumors. The study focuses on gathering knowledge about the disease mechanisms and identifying new biomarkers to improve diagnosis and therapy. It also plans to build a clinical data and sample repository for future insulinoma research. Participants will be admitted to the Clinical Center of the National Institutes of Health for evaluation and treatment based on their specific condition and standard care practices. During the study, patients will undergo tests including fasting blood sugar measurements, insulin level assessments, and other diagnostic procedures related to insulin secretion. Medical and surgical care will be provided as needed under supervision. Throughout participation, patients will be monitored regularly every 1 to 3 months to assess treatment outcomes. The study involves blood tests and clinical evaluations to track progress and response to therapy. Participants can expect thorough medical supervision and repeated assessments to better understand their condition over time.
CONDITIONS
Diagnosing and Treating Low Blood Sugar Levels
C
Craig S Cochran, R.N.
R
Ranganath Muniyappa, M.D.
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 to 2 visits for eligibility assessments
Duration - Duration varies by participant based on individual treatment plan
Participants undergo fasting blood sugar and insulin tests, receive diagnosis, and are treated according to their condition with medical or surgical care as needed.
Regular visits every 1 to 3 months for monitoring and treatment assessment
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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R S Bar, P Gorden, J Roth...
https://pubmed.ncbi.nlm.nih.gov/194912/R J Comi, P Gorden
https://pubmed.ncbi.nlm.nih.gov/3568598/P J Blackshear, H E Rotner, K A Kriauciunas...
https://pubmed.ncbi.nlm.nih.gov/6349454/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lead Sponsor