Actively Recruiting
Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction
Led by Medical University of Silesia · Updated on 2026-05-19
100
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Heart failure with reduced ejection fraction (HFrEF) often leads to loss of muscle mass and sarcopenia, which can reduce exercise ability, quality of life, and increase mortality risk. Despite new drug treatments, there are few proven non-drug approaches to prevent muscle loss. This trial aims to study how a high-protein DASH diet, resistance exercise, and their combination affect muscle mass, heart function, lab markers, and quality of life in people with HFrEF. Participants are randomly assigned to one of four groups: standard medical care, resistance exercise training using elastic bands guided by a rehabilitation specialist, a personalized 14-day DASH diet meal plan with high protein, or a combination of both diet and exercise. These interventions are designed to be followed over a 6-month period. During the study, participants will have their skeletal muscle mass measured at the start and after 6 months. Researchers will also monitor exercise ability, quality of life, heart ultrasound parameters, and laboratory tests. This study focuses on how these combined lifestyle changes might improve health outcomes in HFrEF patients over the six-month duration.
CONDITIONS
Brief Title
Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide written informed consent before participating
- Age over 30 years
- Diagnosed with chronic heart failure, NYHA functional class I to III
- Left ventricular ejection fraction less than 40%
You will not qualify if you...
- NYHA functional class IV heart failure
- Heart failure caused by potentially reversible factors
- Estimated glomerular filtration rate below 30 mL/min
- Severe anemia with hemoglobin under 9 g/dL
- Uncontrolled thyroid disease
- Severe liver dysfunction
- History of or current hyperkalemia
- Epilepsy
- Presence of joint endoprostheses
- Gastrointestinal disorders that limit adherence to the DASH diet
- Physical limitations preventing participation in structured exercise
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months
Participants receive behavioral interventions including resistance exercise training, dietary intervention, or a combination of both based on their assigned group.
Regular visits for intervention and monitoring
Trial Site Locations
Total: 1 location
1
2nd Department and Clinical Ward of Cardiology Specialist Hospital in Zabrze, Poland
Zabrze, Silesian Voivodeship, Poland, 41-800
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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