Evaluating Asymmetric and Bilateral Temporal Interference Stimulation on Both Sides of the Brain to Improve Movement and Speech in Parkinsons Disease

What this Trial Is About

Researchers are evaluating the effectiveness of accelerated Temporal Interference Stimulation TIS as a treatment for individuals diagnosed with Parkinsons disease. The study aims to determine if delivering different TIS frequencies to the bilateral subthalamic nuclei can improve motor function and speech. Functional MRI scans will also be used to observe changes in brain activity caused by the TIS intervention. The trial uses a two-arm parallel design comparing asymmetric frequency stimulation with bilateral same-frequency stimulation. Participants will receive targeted TIS either with an asymmetric frequency protocol 130 Hz on the side opposite the most severe symptoms and 60 Hz on the other side or with bilateral 130 Hz stimulation as a control. Treatments are applied twice daily, each session lasting 40 minutes, with at least one hour between sessions. Personalized electrode placement and current intensity are determined using each patients MRI data. The intervention lasts for five consecutive days under standardized conditions. During the trial, participants will undergo brain fMRI scans and complete motor and speech function assessments before and after the intervention course. Researchers will measure scores on Parkinsons disease rating scales, balance and walking tests, voice intensity, and brain imaging changes. All adverse events and symptoms will be recorded throughout the intervention and follow-up period, which lasts one month after treatment. This will help assess the safety and impact of the different TIS frequencies on Parkinsons disease symptoms.

Different Frequency Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease