Actively Recruiting
Digestibility of Different Plant-based Proteins in Humans With Ileostomy
Led by Örebro University, Sweden · Updated on 2025-08-14
11
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this interventional study is to learn about the digestibility of different plant-based proteins in adults (age 18-75) with an ileostomy. The main questions the study aims to answer are: 1. How does the digestibility of proteins in the small intestine differ between different plant-based proteins? 2. Which proteins and amino acids are not digested or absorbed in the small intestine and are available for further metabolic processes in the large intestine? 3. How do metabolites in the collected content of the ileostomy bag differ after consuming different plant-based proteins? 4. Can the in vivo results be compared to results from existing in vitro models? Participants will consume five different protein meals (oat protein - high bioavailable, oat protein - low bioavailable, pea protein - high bioavailable, pea protein low bioavailable, protein-free meal) on five different study days in a random order. Five hours after consuming the test meals ileostomy bags will be collected and the content will be analysed to answer the above mentioned research questions.
CONDITIONS
Official Title
Digestibility of Different Plant-based Proteins in Humans With Ileostomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Body mass index between 18.5 and 30 kg/m2
- Having a (double-loop) ileostomy with an intact small bowel
- Signed informed consent to participate
You will not qualify if you...
- Pregnancy or breastfeeding
- Ileostomy less than 3 months old
- Any significant current or past disease/condition except colon cancer that could affect study results
- Any significant current or past medication that could affect study results
AI-Screening
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Trial Site Locations
Total: 1 location
1
Örebro University
Örebro, Sweden, 70182
Actively Recruiting
Research Team
R
Robert Brummer, PhD
CONTACT
A
Annalena Kamm, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
11
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