Study of Digestibility of Various Plant-Based Proteins in Adults with Ileostomy Using a Human Ileostomy Model

What this Trial Is About

This research aims to understand how different plant-based proteins are digested in adults aged 18 to 75 with an ileostomy. The study focuses on comparing protein digestibility in the small intestine, identifying proteins and amino acids that reach the large intestine, analyzing metabolites in ileostomy bag contents, and comparing these findings with existing laboratory models. Participants will consume five different meals on five separate study days in a random order. These meals include oat protein with high and low bioavailability, pea protein with high and low bioavailability, and a protein-free meal. On each study day, five hours after eating, the content of the ileostomy bag will be collected for analysis. During the study, participants will attend five visits to consume the meals and provide ileostomy bag samples. Researchers will assess protein digestibility and metabolite profiles from 0 to 5 hours after meal consumption. The study will use this data to compare in vivo digestion with in vitro results. Participation involves monitoring protein digestion over these multiple visits to better understand plant protein absorption in the small intestine.

Digestibility of Different Plant-based Proteins in Humans With Ileostomy