Actively Recruiting
Dissecting the Molecular and Cellular Pathophysiology of Sarcopenic Obesity in the Elderly
Led by IRCCS San Raffaele · Updated on 2025-06-18
1108
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates sarcopenic obesity (SO) in older adults, a condition combining obesity and loss of muscle mass and function. SO presents a growing health challenge in the elderly, increasing the risk of disability. The study aims to identify early molecular and cellular markers that could help recognize those at risk and guide more personalized treatment approaches. It is a cross-sectional observational study conducted over two years involving elderly individuals. Participants include two groups: patients aged 65 and older who are candidates for hip surgery, and healthy elderly subjects from a previous cohort who were overweight or obese but had not developed sarcopenia. Both groups undergo clinical evaluations including questionnaires, blood sampling, and muscle ultrasound scans to collect data on their muscle and fat composition and function. During the study, participants complete scales and questionnaires, have blood samples taken, and receive muscle ultrasound scans. Researchers will measure new molecular markers related to sarcopenic obesity and assess their ability to predict disease progression. The study is sponsored by IRCCS San Raffaele and will run until the end of 2025, aiming to improve understanding of sarcopenic obesity's impact on health and quality of life.
CONDITIONS
Brief Title
Dissecting the Molecular and Cellular Pathophysiology of Sarcopenic Obesity in the Elderly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who are candidates for hip surgery
- Age 65 years or older
- Patients able to give consent
- Healthy subjects from the geriatric cohort studied in 2016-2017 who were overweight (BMI 25 to <30 kg/m2) or obese (BMI 30 kg/m2 or more) but had not developed sarcopenia
You will not qualify if you...
- Unavailability to participate in the study
- Inflammatory or neurological myopathies
- Acute heart failure
- Active cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - May 2023 to October 2024
Participants complete scales and questionnaires, undergo venous blood sampling, and have a muscle ultrasound scan to evaluate sarcopenic obesity.
1 to 2 visits depending on cohort assignment
Duration - May 2023 to October 2024
Participants are observed over time to assess molecular markers and predict disease trajectories related to sarcopenic obesity.
Follow-up assessments as scheduled during the study period
Trial Site Locations
Total: 1 location
1
Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
Research Team
P
Patrizia Rovere Querini, PhD, MD
R
Rebecca De Lorenzo, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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