Understanding the Molecular and Cellular Causes of Sarcopenic Obesity in Older Adults A Study of Patients Needing Hip Surgery and Healthy Elderly Individuals

What this Trial Is About

This research investigates sarcopenic obesity SO in older adults, a condition combining obesity and loss of muscle mass and function. SO presents a growing health challenge in the elderly, increasing the risk of disability. The study aims to identify early molecular and cellular markers that could help recognize those at risk and guide more personalized treatment approaches. It is a cross-sectional observational study conducted over two years involving elderly individuals. Participants include two groups patients aged 65 and older who are candidates for hip surgery, and healthy elderly subjects from a previous cohort who were overweight or obese but had not developed sarcopenia. Both groups undergo clinical evaluations including questionnaires, blood sampling, and muscle ultrasound scans to collect data on their muscle and fat composition and function. During the study, participants complete scales and questionnaires, have blood samples taken, and receive muscle ultrasound scans. Researchers will measure new molecular markers related to sarcopenic obesity and assess their ability to predict disease progression. The study is sponsored by IRCCS San Raffaele and will run until the end of 2025, aiming to improve understanding of sarcopenic obesitys impact on health and quality of life.

Dissecting the Molecular and Cellular Pathophysiology of Sarcopenic Obesity in the Elderly