Study of DNA Methylation and Vascular Health in Adults with Obesity Effects of Aerobic Exercise and Weight Loss Surgery

What this Trial Is About

Researchers are investigating how DNA hypomethylation may contribute to increased inflammatory cytokine production and impaired blood vessel function in obese adults. This study focuses on adults aged 18 to 50 with obesity and aims to explore DNA hypomethylation as a potential target for non-drug interventions like aerobic exercise and weight loss. The goal is to better understand and develop strategies to prevent and treat cardiovascular disease linked to obesity. Participants will be randomly assigned to one of two groups one group will undergo 12 weeks of aerobic exercise training, while the other will receive standard care without exercise. The study also includes examining the effects of weight loss after bariatric surgery on DNA methylation and vascular function. These approaches are being studied to see if they can reverse DNA hypomethylation and improve blood vessel health in obese individuals. During the study, participants will have fat tissue samples collected to analyze DNA methylation patterns and will undergo assessments of vascular health using various biomarkers and flow-induced dilation measurements. The primary outcome is the DNA methylation status of adipocytokines measured between months 24 and 30. Secondary outcomes include changes in vascular health markers before and after exercise training. The study duration and follow-up ensure careful monitoring of the effects of exercise and surgical weight loss on obesity-related vascular dysfunction.

DNA Methylation and Vascular Function