Actively Recruiting
Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study
Led by University Hospital, Grenoble · Updated on 2025-01-20
20
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate if new, early biomarkers of the disease are available in presymptomatic genetic carriers of Huntington\'s diesase compared to healthy subjects. The main questions it aims to answer are: Does functional brain MRI is able to detect early biomarkers of the disease in genetic carriers? Does gait study by a virtual reality device can detect early biomarkers of the disease in genetic carriers? Researchers will compare genetic carriers and healthy subjects to see if new, early biomarkers of the disease can be detected .
CONDITIONS
Official Title
Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For premanifest Huntington's disease gene carriers: confirmed genetic diagnosis with CAG triplets 36 or more in HTT gene
- Total Motor Score on Unified Huntington Disease Rating Scale of 5 or less
- Age between 18 and 70 years old
- For healthy controls: normal neurological examination
- Age between 18 and 70 years old
You will not qualify if you...
- Major active eye diseases
- Major active psychiatric diseases
- Cognitive impairment with Montreal Cognitive Assessment (MoCA) score less than 25
- Gait problems caused by non-neurological conditions
- Contraindications to brain MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Grenoble University Hospital
Grenoble, France, 38043
Actively Recruiting
Research Team
S
Sara Meoni, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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