Study of Early Signs of Long-Term Complications in Children and Teens with Type 1 Diabetes

What this Trial Is About

Researchers are investigating early signs of long-term complications in children and adolescents aged 6 to 18 years with type 1 diabetes T1D for more than 12 months. The study aims to understand how glucose control, glucose variability, and insulin sensitivity relate to early markers such as arterial stiffness, nerve dysfunction, and kidney changes. This research hopes to identify subgroups of young patients who may benefit from earlier screening and possible preventive measures to reduce complications and improve long-term health outcomes. The study is designed as a one-day cross-sectional visit where 400 participants will undergo thorough examinations after fasting overnight. Assessments include physical exams with heart and blood pressure checks, extensive blood sampling for metabolic markers, nerve function tests using non-invasive devices, kidney tests from urine samples, bone age X-rays, body composition scans, liver stiffness measurement, eye exams, and continuous glucose monitoring for at least 14 days. Physical activity will be tracked for 7 days, and questionnaires on lifestyle and quality of life will be completed. A subgroup of pubertal boys will have a special insulin sensitivity test using a hyperinsulinemic-euglycemic clamp. Participants will provide medical history including diabetes duration and treatment details. Researchers will collect data on past blood tests and diabetic complication status. Follow-up visits will be offered every 5 years for the next 20 years to monitor progression. The study measures arterial stiffness, nerve function, and other early complication markers and their relation to glucose control. Outcomes will help improve understanding of diabetes management and early detection of complications. The total participation involves a single detailed visit with extended monitoring and long-term follow-up opportunities.

Early Detection of Long-term Diabetic Complications in Children and Adolescents With Type 1 Diabetes