Actively Recruiting
Led by Centre Hospitalier Intercommunal Creteil · Updated on 2025-06-13
10400
Participants Needed
1
Research Sites
104 weeks
Total Duration
This research aims to compare two methods of early screening to identify infants at risk for Autism Spectrum Disorder and Neurodevelopmental Disorders. It targets infants under 12 months of age to provide early access to care, hoping to improve outcomes by detecting developmental delays compared to typical age expectations. The study is conducted at multiple Maternal and Child Protection Services in France and follows infants up to 48 months of age. Two screening approaches are evaluated during routine visits for vaccinations or developmental exams at 4 and 9 months. One method involves a health professional assessing neurodevelopment through routine observations of motor skills, vocalizations, babbling, and social interactions. The other method uses the PREAUT grid, a specific screening tool for autism spectrum disorders. Infants showing abnormal results are referred promptly to specialized centers for further advice and treatment when needed. Participants will have follow-ups at 12, 24, and 36 months including developmental assessments like the Modified Checklist for Autism in Toddlers and the Child Development Inventory. Additional diagnostic tools are used if initial tests indicate concerns. The study also collects data on treatments received, parental psychological state, quality of life, and family impact. Health insurance data will track care pathways up to 48 months. The main outcome is the proportion of children diagnosed and receiving care before age one.
CONDITIONS
Early Detection and Referral for Autism and Neurodevelopmental Disorders at the Maternal and Child Protection Services
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during routine medical follow-up
Duration - At 4 and 9 months of age
Participants undergo neurodevelopmental assessments using either routine practice evaluations or the PREAUT grid to detect early signs of developmental gaps or autism spectrum disorder.
2 visits aligned with routine vaccination and developmental examinations
Duration - Up to 36 months
Participants are followed up at 12, 24, and 36 months to assess development, including screenings with M-CHAT-R/F and IDE tests, and additional diagnostic assessments if results are abnormal.
Visits at 12, 24, and 36 months with additional assessments as needed
Duration - Up to 48 months
Participants' care pathways are monitored using health insurance claims data to evaluate treatments and interventions received up to 48 months of age.
No additional visits; data collected through health records
Total: 1 location
1
PMI Stalingrad
Champigny-sur-Marne, France, 94500
Actively Recruiting
C
Catherine DELMAS, MD
C
Camille JUNG, MD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Catherine Delmas, Xavier Xu Wang, Anne-Sylvie Pelloux...
https://pubmed.ncbi.nlm.nih.gov/40759525