Actively Recruiting
Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.
Led by Mona Lichtblau · Updated on 2026-05-01
18
Participants Needed
1
Research Sites
198 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with past HAPE responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with past HAPE. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The "altitude" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.
CONDITIONS
Official Title
Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Diagnosed or suspicion of past HAPE
- Age between 18 and 80 years
- All sexes and genders
- Living below 800 meters without exposure above 2500 meters for over 24 hours in the last three weeks
You will not qualify if you...
- Younger than 18 or older than 80 years
- Any other diagnosed heart or lung condition
- Any other severe medical condition such as kidney or liver problems
- Inability to follow study procedures due to language, psychological, neurological, or orthopedic issues
- Living permanently above 800 meters or exposed above 2500 meters for more than 24 hours in the last three weeks
- Pregnancy or lactation
- Participation in another study with active treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Consultant Clinic of Pulmonology, University Hospital of Zurich
Zurich, Switzerland, 8091
Actively Recruiting
Research Team
M
Mona Lichtblau, PD Dr. med.
CONTACT
C
Carmen Wick, Cand. PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
6
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