Actively Recruiting
The Effect of Respiratory and Aerobic Exercises on Neuroprotective and Inflammation Biomarkers in Patients Diagnosed With Major Depression
Led by Kutahya Health Sciences University · Updated on 2025-09-05
40
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
K
Kutahya Health Sciences University
Lead Sponsor
S
Scientific Research Projects Coordination Unit
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to explore how breathing exercises and aerobic exercise affect certain biomarkers linked to neuron development and inflammation in adults diagnosed with major depression. The study focuses on biomarkers such as IGF-1, FGF2, and EGF involved in neuron growth, as well as inflammatory markers like TNF-α, IL-6, IL-1, and oxidative stress indicators including TAS, TOS, MDA, and F2-isoprostane. These factors are thought to play a role in the biology of depression. Participants are randomly assigned to either an experimental group or a control group. Those in the experimental group perform daily diaphragmatic breathing exercises and walking exercises at least three days a week for three weeks. The breathing exercises gradually change position from lying down to standing over the weeks, while the walking is done at 80% intensity for at least 30 minutes per session. The control group continues their normal routine without added exercises during this period. Throughout the three-week study, researchers monitor changes in oxidative stress and proinflammatory cytokines from the start to the end of treatment. Participants' adherence to the breathing and aerobic exercises is tracked, and assessments focus on how these activities influence the target biomarkers. The total participation duration is three weeks, during which the effects of the prescribed exercises on depression-related biological markers are evaluated.
CONDITIONS
Brief Title
Effect of Aerobic Exercise on Biomarkers in Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals who volunteer to participate in the study
- Between the ages of 18 and 40
- Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria
You will not qualify if you...
- Individuals with chronic conditions accompanying depression
- Those with walking difficulties
- Those with respiratory system disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 weeks
Participants in the experimental group perform diaphragmatic breathing exercises daily and aerobic walking exercises at least three days a week for three weeks. The control group continues their routine lives during this period.
Multiple exercise sessions at home during the 3 weeks; at least 3 walking sessions weekly
Trial Site Locations
Total: 1 location
1
Kutahya Health Sciences University
Kütahya, Merkez, Turkey (Türkiye), 43020
Actively Recruiting
Research Team
H
Hatice Solak, Assos. Prof
V
Vedat Kurt, Assos. Prof.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here