Actively Recruiting
Effect of Agricultural Practices on Crops, Gut Microbiome, and Human Health
Led by Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC) · Updated on 2025-09-10
44
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The human gut microbiome plays a regulatory role in host health, and is involved in metabolic, immune, and neurological processes. Diet shapes the gut microbiome; by providing essential nutrients, which sustain the existing microorganisms and by introducing foodborne microbes that modulate its composition. Notably, the impact of microbes from fruit and vegetables on the gut microbiome is relatively unexplored. Differences in agricultural practices, organic vs conventional strategies, can lead to variations in nutritional content and associated microbial communities in and on crops, underscoring the potential for variations in cultivated crops to influence the human gut microbiome's composition and function. This study aims to explore how crop cultivation practices affect the composition and function of the human gut microbiome, ultimately influencing overall health.
CONDITIONS
Official Title
Effect of Agricultural Practices on Crops, Gut Microbiome, and Human Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy Caucasian adults aged 18 to 45 years with BMI less than 25 kg/m2 and no medical conditions
- Caucasian adults aged 18 to 45 years with BMI between 28 to 40 kg/m2 having three components of Metabolic Syndrome and drug-nafve
- Elevated waist circumference (>102 cm for men, >88 cm for women)
- High fasting plasma glucose level (≥110 mg/dL or 6.1 mmol/L)
- High fasting plasma insulin level (≥25 bcU/mL or >16.7 pmol/L)
- HOMA-IR score of 2.5 or higher
You will not qualify if you...
- Use of antibiotics within the past 3 months or current use
- Currently or previously following vegan, strictly organic, or vegetarian diets
- Severe food allergies or intolerances that prevent consuming the provided fruits and vegetables
- Unable or unwilling to collect stool samples
- Presence of type 1 or type 2 diabetes
- Use of medications for type 2 diabetes including metformin, statins, proton pump inhibitors, H2 blockers, pioglitazone, or GLP-1 receptor agonists
- Prior or planned bariatric surgery or history of cholecystectomy
- History of cardiovascular disease or severe digestive diseases such as celiac disease, Crohn's disease, or active ulcerative colitis
- Scheduled surgery during the study period
- Pregnant or breastfeeding women
- Smoking, illicit drug use, or consuming more than 5 units of alcohol daily on average
- History of neurological or neurodegenerative disorders
- Participation in another clinical trial during the study
- Not residing in the Netherlands during September to November 2025
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Amsterdam UMC, locatie AMC
Amsterdam, Amsterdam, Netherlands, 1105 AZ
Actively Recruiting
Research Team
M
Max Nieuwdorp, Prof., Dr.
CONTACT
H
Hilde H.J. Herrema, PhD.,
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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