Comparison of Antimicrobial Efficacy of Diode Laser, Ultrasonic Activated and Conventional Irrigation with 2.5% NaOCl during RCT: An Interventional Study.
Nikhil Jambagi, Preeti Kore, Neha S Dhaded...
https://pubmed.ncbi.nlm.nih.gov/34393125Actively Recruiting
Phase Not Applicable
Age: 25Years - 60Years
All Genders
ID07549373
Antibacterial Effect of 940nm Diode Laser, Apple Cider Vinegar, and Gymnema Sylvestre in Diabetic Patients with Apical Periodontitis Against Peptostreptococcus Species - A Randomized Clinical Trial
Led by Sharda University · Updated on 2026-05-28
90
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research evaluates the antibacterial effects of different disinfection methods during root canal treatment in patients with type 2 diabetes and apical periodontitis. The study is a randomized controlled clinical trial conducted over one year, aiming to detect Peptostreptococcus species in infected root canals. The trial compares the use of a 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre, and combinations of these against standard saline irrigation in diabetic patients aged 25 to 60 years. Participants undergo standard root canal treatment with aseptic isolation and access cavity preparation. Working length is determined by electronic apex locator and radiography. Canals are instrumented and irrigated using 5% sodium hypochlorite and 17% EDTA. They are then randomly assigned to one of six groups receiving either saline, apple cider vinegar, diode laser, Gymnema Sylvestre solution, or combinations of diode laser with apple cider vinegar or Gymnema Sylvestre. Post-disinfection microbial samples are collected for PCR analysis. Patients are followed up at 7, 15, 30, 45, and 60 days after treatment. Clinical outcomes are assessed using periapical radiographs and the Periapical Index (PAI). Pain intensity is measured by the Visual Analog Scale (VAS). Microbial presence of Peptostreptococcus species is monitored over one year using PCR. The study also tracks pain levels and treatment effects through repeated assessments during the follow-up period.
CONDITIONS
Brief Title
Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Who Can Participate
Age: 25Years - 60Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients with primary endodontic infection confirmed by intraoral periapical radiographs (RVG)
- Multirooted teeth with root periapical lesion
- Type 2 diabetic patients aged 25 to 60 years, both male and female
- Fasting blood sugar level of 126 mg/dl or higher and random blood sugar less than 200 mg/dl
- HbA1c (glycated haemoglobin) level of 6.5% or greater
You will not qualify if you...
- Patients with systemic conditions other than type 2 diabetes
- Pregnant women
- Patients who have used antibiotics within the previous three months
- Teeth with developmental defects or calcified canals
- Teeth that cannot be isolated with rubber dams
- Teeth with tortuous canals
- Teeth with fractured roots
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Single treatment session with immediate post-treatment sampling
Participants undergo root canal treatment with different disinfection protocols including diode laser, apple cider vinegar, Gymnema Sylvestre, or combinations, to reduce bacterial infection in diabetic patients.
1 treatment visit (in-person)
Follow-up
Duration - 60 days post-treatment
Participants are followed up to assess clinical outcomes, pain levels, and bacterial detection through multiple visits.
5 follow-up visits at 7, 15, 30, 45, and 60 days (in-person)
Trial Site Locations
Total: 1 location
1
Dr Lakshmi Pandey
Noida, Uttar Pradesh, India, 201310
Actively Recruiting
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Research Team
L
Lakshmi Pandey, MDS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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Published Research Related To This Trial
An in vivo comparison of the antibacterial efficacy of photoactivated disinfection, diode laser, and 5% sodium hypochlorite in root canal disinfection.
Snehal S Sonarkar, Shishir Singh, Rajesh Podar...
https://pubmed.ncbi.nlm.nih.gov/29674826Antifungal Activity of Apple Cider Vinegar on Candida Species Involved in Denture Stomatitis.
Ana Carolina Loureiro Gama Mota, Ricardo Dias de Castro, Julyana de Araújo Oliveira...
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Fatemeh Owlia, Faezeh Zarezadeh, Sara Jambarsang...
https://pubmed.ncbi.nlm.nih.gov/36148044PCR-based detection of three anaerobic bacteria associated with endodontic-periodontic lesions in type-2 diabetic and nondiabetic subjects.
Rakesh Rajeevan Nair, Moksha Nayak, L Krishna Prasada...
https://pubmed.ncbi.nlm.nih.gov/33082657