Investigation of the Effects of Standard Rehabilitation Program and Inspiratory Muscle Training on lncRNA HOTAIR Expression in Patients With Rheumatoid Arthritis

What this Trial Is About

This research aims to explore the effects of adding respiratory muscle strengthening training to traditional respiratory rehabilitation for patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). It focuses on understanding how these exercise programs impact genetic changes, exercise capacity, shortness of breath, muscle strength, quality of life, and psychological state in these patients. The study also investigates the regulation of a specific long non-coding RNA, HOTAIR, which is linked to inflammation and joint damage in rheumatoid arthritis. Participants are assigned to one of three groups: a standard pulmonary rehabilitation program involving aerobic, resistance, and respiratory exercises; a similar program with added inspiratory muscle strengthening using a resistive device; or a control group with no intervention. Exercise sessions are supervised remotely twice weekly with an additional home-based session once a week, continuing for 3 months. The control group provides blood samples without engaging in exercise programs. During the study, participants will have assessments before and after the 12 weeks of intervention, including measuring lncRNA HOTAIR expression, respiratory muscle strength, exercise capacity via a 6-minute walk test, and quality of life questionnaires. Additional evaluations cover lung function tests, dyspnea scales, muscle strength, and physical activity levels. The study monitors changes in these outcomes to understand the effects of respiratory rehabilitation and muscle training on RA-ILD patients over the study period.

The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis