Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate: a Prospective Randomized Trial

What this Trial Is About

Researchers are evaluating whether using a hyaluronan-enriched transfer medium can increase the cumulative ongoing pregnancy rate in women undergoing embryo transfer. This prospective randomized trial compares the effects of this enriched medium to the conventional culture medium in patients planning multiple oocyte retrievals but with no ongoing clinical pregnancy from previous attempts. The study is sponsored by KU Leuven and aims to better understand how the transfer medium influences pregnancy success. Participants are randomly assigned to one of two groups: one group receives embryo transfer using the hyaluronan-enriched medium, while the control group receives embryo transfer with the standard culture medium. The study follows a double-blind design to ensure unbiased results. The primary outcome is the number of transfers needed to reach an ongoing pregnancy, defined by a viable fetus with fetal heartbeat at 12 weeks. Secondary outcomes include transfers needed to reach clinical pregnancy, live birth, miscarriage, and multiple pregnancy. Participants will be monitored through their embryo transfer cycles until an ongoing pregnancy or live birth occurs. Researchers will track pregnancy status, including fetal heartbeat and clinical outcomes up to nine months after embryo transfer. Women aged 18 to 40 with their own oocytes or embryos, and a BMI of 32 or less, who have had no ongoing pregnancy after previous retrievals, are eligible. The study includes informed consent and follows participants until the measured outcomes are achieved or the study ends.

Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate.