Study of How Obesity, Diabetes, and Bariatric Surgery Affect Pregnancy and Baby Outcomes

What this Trial Is About

Researchers are studying how obesity, diabetes, and previous bariatric surgery affect pregnancy outcomes. The study focuses on pregnant women with normal weight, overweight, obesity, and glucose disorders like gestational diabetes and type 2 diabetes. It also compares pregnancies of women who have had bariatric surgery to those without surgery but with similar body mass index BMI before and during pregnancy. This research aims to understand the maternal and fetal environment and health during and after pregnancy. This observational study involves multiple groups pregnant women with obesity or glucose disorders, women with normal BMI without diabetes, women with prior bariatric surgery, and matched control groups without surgery. Participants will be followed during pregnancy at several time points between 12 and 37 weeks gestation, and after birth at 6 weeks, 3 months, 12-24 months, and 3-7 years. Various tests including ultrasounds, echocardiography, blood and urine sampling, and neonatal MRI will be performed. Participants will have their medical history recorded and undergo measurements such as weight, height, blood pressure, and blood sugar testing. Fetal growth and wellbeing will be assessed using ultrasound techniques. Samples from mother and baby will be collected at delivery and during postnatal visits. The main outcome measured is birth weight percentiles, with additional monitoring of pregnancy complications, labor outcomes, and long-term health of mother and child. The study lasts several years with follow-up visits scheduled up to 7 years after birth.

Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes