Evaluating the Effect of Pre-Exercise Molecular Hydrogen Inhalation on Metabolic Response in Healthy Women Aged 18 to 30

What this Trial Is About

Researchers are studying the effect of molecular hydrogen inhalation on the metabolic response during graded exercise in healthy women aged 18 to 30 years. This trial aims to find out whether molecular hydrogen reduces the respiratory exchange ratio and oxygen uptake compared to a placebo. The study uses a crossover design where participants receive both treatments in random order to assess metabolic changes. Participants undergo two interventions, each lasting 7 days, where they inhale either molecular hydrogen gas at a concentration of 3.75% mixed with ambient air or a placebo consisting of ambient air without hydrogen. The gas is delivered daily for 60 minutes through a face mask connected to a specialized system. After each intervention week, participants perform a graded exercise test on a bicycle ergometer with increasing workload to measure metabolic variables. During the study, participants are assessed at rest and during exercise for various outcomes including cardiorespiratory measures, blood biomarkers, and perceived exertion. The metabolic response is monitored through changes in respiratory exchange ratio, oxygen uptake, carbon dioxide production, ventilation, breathing frequency, heart rate, blood lactate levels, and exertion ratings. The study uses a two-week washout period between interventions and applies statistical analysis to compare results. Total participation spans the two intervention periods and washout, with repeated testing to evaluate the effects.

Effect of Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women