Study of a New Probiotic Supplement to Improve Appetite Control and Gut Health in Adults With Overweight or Obesity

What this Trial Is About

Researchers are investigating the effects of a newly developed probiotic supplement on feelings of fullness and gut microbiota composition in healthy adults aged 20 to 70 years who are overweight or obese. This 16-week randomized, placebo-controlled study aims to determine whether the probiotic increases satiety and beneficially changes gut bacteria, which may influence food intake and weight management. The study includes 98 participants with a body mass index between 26 and 40 kgm2, comparing the probiotic to a placebo. Participants will take a daily dose of 6 grams of either the probiotic supplement or placebo, provided in sachets of 3 grams, for 16 weeks. They will visit the research unit three times at the start, week 8, and week 16, to provide blood samples and fecal specimens. Participants will also keep a diary to record any changes in their daily habits and complete food questionnaires to track diet. During the study, researchers will assess food intake by measuring ad libitum consumption and analyze satiety hormones such as GLP-1. They will also study changes in gut microbiota, insulin sensitivity, inflammatory markers, lipid metabolism, body composition, and mental health. The study includes various questionnaires and physical measurements to monitor health and appetite-related factors throughout the 16 weeks of intervention.

Effect of Probiotics on Appetite Regulation in Adults With Overweight/Obesity