Actively Recruiting
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
Led by Emory University · Updated on 2026-02-27
84
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate how different nicotine concentrations and pH levels in nicotine pouches affect sensory experience, product appeal, and abuse liability among young adult users. Nicotine pouches (NPs) are a growing category of nicotine products that contain nicotine but no tobacco leaf and dissolve in the mouth without spitting. Their increasing popularity raises health concerns due to efficient nicotine delivery and potential for dependence and harmful effects. Participants will self-administer nicotine pouches that vary by two factors: nicotine concentration (low, about 3-4 mg, versus high, about 6-8 mg) and pH level (low pH below 8.5 and high pH 8.5 or above). Each participant will experience all four possible combinations in randomized order, receiving one condition per visit. The study will occur over 2 to 4 weeks with four visits total. During each visit, researchers will measure how long participants use the nicotine product and the number of pouches consumed. Participants will also complete questionnaires about subjective effects, product appeal, and sensory attributes. Additional data on recent nicotine product use history will be collected. The trial includes safety monitoring and aims to understand factors that influence nicotine pouch use and abuse in young adults aged 21 to 35 years.
CONDITIONS
Brief Title
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current established users of nicotine pouches who have used them in the past 30 days and currently use every day or some days
- Positive cotinine test via saliva test strip
- Not motivated to quit nicotine use
- Able to read and speak English
- Poly-users of nicotine pouches, e-cigarettes (vaping 20 or more days per month), and tobacco (4 or more cigarettes per day for 2 or more years) are eligible
You will not qualify if you...
- Planning to reduce or quit nicotine use in the next 30 days
- Currently pregnant or breastfeeding
- History of stroke, seizures, high blood pressure, heart disease, or cardiovascular disease contraindications for nicotine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Duration - Within 2 to 4 weeks
Participants self-administer nicotine pouches that vary by nicotine concentration and pH level. Each participant uses all four nicotine pouch conditions in a randomized order, with one condition per visit.
4 visits (in-person)
Trial Site Locations
Total: 1 location
1
Rollins School of Public Health
Atlanta, Georgia, United States, 30322
Actively Recruiting
Research Team
D
Dae Hee Han, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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