Actively Recruiting
Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries
Led by National University Hospital, Singapore · Updated on 2025-11-21
93
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Recent clinical trials comparing pulpotomy versus root canal treatment (RCT) have shown promising outcomes; however, the current evidence lacks generalisability to general practitioners. It remains to be elucidated whether these favourable results can be replicated in a primary care setting. This study aims to address that gap by involving senior dental students undergoing supervised university education and training, with the potential to inform future best practice guidelines and promote the adoption of vital pulp therapy (VPT) as a predictable treatment alternative in the general dental population. The clinical procedure involves complete caries-free excavation carried out under rubber dam isolation. After confirming vital pulp status-demonstrated by bleeding upon entry, participants will be randomised to receive one of two treatments: RCT or full pulpotomy. Outcomes will include clinical and radiographic success or failure of the intervention at 12 months. Additionally, patient-reported outcomes will be collected, specifically pain experienced and the use of analgesia during the immediate post-operative period (days 3 and 7).
CONDITIONS
Official Title
Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 12 years or older
- Mature maxillary or mandibular permanent tooth with extremely deep restorations or caries penetrating the entire thickness of dentine on radiograph without a radiopaque zone separating the lesion from the pulp
- Tooth may be symptomatic or not but must respond to cold and electric pulp tests
- Tooth is restorable and can be adequately isolated during treatment
- Only one tooth per patient
You will not qualify if you...
- Teeth with difficult access and unpredictable isolation using a rubber dam
- Teeth with aberrant root canal morphology, extreme root curvatures greater than 30 degrees, or calcified canals/sclerosed pulp
- Teeth indicated for elective root canal treatment for restorative purposes
- Teeth with apical periodontitis
- Presence of apical radiolucency
- Evidence of purulence or excessive bleeding not controlled with cotton pellet and 1.25% hypochlorite for 10 minutes
- History of trauma to the tooth
- Teeth with active periodontal disease with pocket depth greater than 5 mm
- Patients with complex medical histories affecting caries experience and healing, such as immunocompromise or radiotherapy
- Patients who are pregnant or breastfeeding
- Patients unable to consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
National University Centre For Oral Health Singapore (NUCOHS)
Singapore, Singapore
Actively Recruiting
Research Team
V
Victoria Yu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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