Actively Recruiting
Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-04-30
96
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
C
CH CORBIE
Collaborating Sponsor
AI-Summary
What this Trial Is About
Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts. This study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.
CONDITIONS
Official Title
Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy, athletic men practicing track and field for 10 to 12 hours per week
- Age between 19 and 25 years old
- Social security coverage
- Signed informed consent
You will not qualify if you...
- Age over 26 years
- Physical activity less than 8 hours per week
- Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb within the last 8 months
- Exposure to altitude of 2500m or higher within 15 days prior to the protocol
- Arterial hypotension defined as systolic blood pressure below 90 mmHg or diastolic below 60 mmHg
- Drop in systolic blood pressure greater than 20 mmHg or diastolic greater than 10 mmHg upon standing
- Dizziness, lightheadedness, or blurred vision upon standing
- Being under guardianship, conservatorship, or deprived of liberty
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHRU Amiens
Amiens, France, 80054
Actively Recruiting
Research Team
Y
Yannis Hamidou, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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