Actively Recruiting
Effects of Hot Baths Before or After Muscle-Lengthening Exercise on Muscle Function and HSP70 Expression in Healthy Young Men
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-04-30
96
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
C
CH CORBIE
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how hot-water immersion before or after muscle-lengthening exercise affects muscle function and the expression of heat shock protein 70 (HSP70) in healthy young athletes. Muscle lengthening causes responses such as strength loss, soreness, immune activity, and increased HSPs, which help protect and repair cells. Combining heat and exercise may enhance these protective responses, but the best timing for heat application is still unknown. Participants will be randomly assigned to one of three groups: hot-water immersion at 41°C 24 hours before exercise, hot-water immersion at 41°C immediately after exercise, or a sham immersion at 36°C after exercise. Immersion sessions last 40 minutes aiming to raise core temperature above 38.5°C for heat stress groups. The study also uses devices like a dynamometer, pressure algometer, and others to assess muscle and physiological responses. During the study, participants will undergo assessments of muscle function and HSP70 concentration over one year. Researchers will monitor core and muscle temperatures and use various tools to measure recovery and physiological changes. The study involves healthy athletic men aged 19 to 25 and includes safety monitoring to track effects over time until the study ends in February 2027.
CONDITIONS
Brief Title
Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male athletes practicing track and field for 10 to 12 hours per week
- Aged between 19 and 25 years old
- Have social security coverage
- Able to provide signed informed consent
You will not qualify if you...
- Older than 25 years
- Less than 8 hours per week of physical activity
- Recent lower limb sprain or ligament rupture within the last 8 months
- Exposure to altitude above 2500 meters within 15 days before the study
- Arterial hypotension with systolic blood pressure below 90 mmHg or diastolic below 60 mmHg
- Significant blood pressure drop or symptoms like dizziness when standing up
- Under guardianship, conservatorship, or deprived of liberty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session per intervention timing
Participants undergo hot-water immersion either 24 hours before muscle-lengthening exercise, immediately after exercise, or a sham immersion at 36°C after exercise to assess muscle function and HSP70 expression.
1 to 2 visits depending on intervention group
Duration - 1 year
Participants are monitored to measure gastro-intestinal temperature, muscle temperature, and HSP70 concentration over the course of one year after intervention.
Periodic visits during the year for assessments
Trial Site Locations
Total: 1 location
1
CHRU Amiens
Amiens, France, 80054
Actively Recruiting
Research Team
Y
Yannis Hamidou, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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