The effect of alcohol consumption on human physiological and perceptual responses to heat stress: a systematic scoping review.
Nathan B Morris, Nicholas Ravanelli, Georgia K Chaseling
https://pubmed.ncbi.nlm.nih.gov/39267036Actively Recruiting
Phase Not Applicable
Age: 19Years +
All Genders
Healthy Volunteers
ID06935045
Evaluating How Alcohol Impacts Physiological Responses and Perception During Heat Exposure
Led by Lakehead University · Updated on 2025-04-18
34
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how alcohol consumption affects physiological responses and perception during conditions similar to indoor extreme heat events. This study focuses on younger and older adults and aims to understand sex- and age-specific changes caused by alcohol intake in heat, building on recent findings that acute alcohol consumption does not negatively affect thermoregulation, hydration, or fluid balance markers compared to control fluids. Participants will be randomly assigned to consume either a placebo non-alcoholic beverage or an alcoholic beverage. Females will receive 0.75 b1 0.1 grams of ethanol per kilogram of body weight, while males will receive 1.0 b1 0.1 grams per kilogram. After consumption, they will rest in a climate-controlled room set at 40 b0C and 30% relative humidity for 120 minutes, with the total study time lasting 180 minutes. During the study, heart rate, skin temperature, core temperature, blood pressure, heart rate variability, arrhythmia presence, skin blood flow, sweat loss, urine output, postural sway, and thermal sensation and comfort will be measured at baseline and every 30 minutes up to 120 minutes after drinking. Blood alcohol concentration and subjective alcohol effects will also be assessed over this period. These measures will help understand how alcohol impacts the body's responses during heat exposure under controlled conditions.
CONDITIONS
Brief Title
Ethanol Consumption in the Heat
Who Can Participate
Age: 19Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Male or female aged 19 years or older
- Able to provide informed consent
You will not qualify if you...
- History of cardiovascular disease, cancer, type 1 or 2 diabetes, chronic obstructive pulmonary disorder, cystic fibrosis, or alcohol addiction or dependence
- Hospitalization due to COVID-19
- Pregnant or breastfeeding
- Scoring eight or above on the Alcohol Use Disorders Identification Test (AUDIT)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Approximately 3 hours for each treatment session
Participants consume either an alcoholic or placebo beverage and rest in a climate controlled room at 40°C and 30% relative humidity while their physiological responses are measured.
2 treatment visits (each with 180 minutes of observation) in a crossover design
Trial Site Locations
Total: 1 location
1
Lakehead University
Thunder Bay, Ontario, Canada, P7B 5E1
Actively Recruiting
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Research Team
N
Nicholas Ravanelli, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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