Actively Recruiting
Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure
Led by University Hospital, Angers · Updated on 2026-04-06
30
Participants Needed
2
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.
CONDITIONS
Official Title
Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older
- Low blood pressure requiring catecholamine medication
- Receiving norepinephrine at a dose of at least 0.1 µg/kg/min at inclusion
- High central venous pressure of 12 mmHg or higher
- Cardiac output monitoring using PICCO or Swan Ganz devices
You will not qualify if you...
- Anuria (no urine output)
- Emergency need for kidney replacement therapy due to severe conditions like high potassium, severe acidosis (pH <7.15), acute lung fluid overload causing serious low oxygen, or high serum urea (>40 mmol/l)
- Pregnant, breastfeeding, or recently gave birth
- Under legal detention or judicial/administrative restriction
- Receiving compulsory psychiatric care
- Under legal protection measures
- Have a do-not-resuscitate order or plans to withdraw life support
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Angers University Hospital
Angers, France
Actively Recruiting
2
Vendée Hospital
La Roche-sur-Yon, France
Actively Recruiting
Research Team
N
Nicolas FAGE, MD
CONTACT
I
Ines ZIRIAT, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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