Chronic Intermittent Hypoxia Exposure Alternative to Exercise Alleviates High-Fat-Diet-Induced Obesity and Fatty Liver.
Yunfei Luo, Qiongfeng Chen, Junrong Zou...
https://pubmed.ncbi.nlm.nih.gov/35563600Actively Recruiting
Phase Not Applicable
Age: 18Years - 50Years
All Genders
ID07073326
Effects of Normobaric Hypoxia Aerobic Training in People With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Led by University of Trieste · Updated on 2026-05-04
20
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of normobaric hypoxic aerobic training on people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). This condition involves metabolic changes such as altered body composition and blood sugar levels. The study aims to evaluate how aerobic training under simulated altitude conditions compares to normal oxygen conditions in improving metabolic health and fitness. Participants will be randomly assigned to one of two groups: one group will perform aerobic training while breathing air with reduced oxygen levels (simulating an altitude of about 2,500 meters), and the other group will perform the same training with normal oxygen levels. Training consists of walking on a treadmill for one hour, two to three times per week, at 60-65% of their maximum heart rate, for eight weeks. Throughout the study, participants will undergo assessments of body weight, fat percentage, oxygen uptake, liver health markers, blood fats, inflammation markers, and blood sugar levels both before and after the eight-week training period. The researchers will monitor these outcomes to understand how the different training conditions affect metabolic health and fitness in people with MASLD.
CONDITIONS
Brief Title
Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Who Can Participate
Age: 18Years - 50Years
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosed with MASLD for at least 3 years
- Body mass index (BMI) greater than 26 kg/m2
- Currently sedentary
You will not qualify if you...
- Cardiovascular, respiratory, or renal complications
- Hypertension
- Chronic obstructive pulmonary disease (COPD)
- Previous history of acute mountain sickness or altitude-related symptoms
- Pregnancy or breastfeeding (females only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 8 weeks
Participants complete 8 weeks of aerobic training on a treadmill 2 to 3 times per week, either with normobaric hypoxic air or normal air while wearing a mask.
2 to 3 sessions per week
Trial Site Locations
Total: 1 location
1
University of Trieste - Exercise Physiology and Kinesiology Lab
Trieste, Trieste, Italy, 34100
Actively Recruiting
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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Published Research Related To This Trial
Hypoxic Training Improves Normoxic Glucose Tolerance in Adolescents with Obesity.
Estelle DE Groote, Florian A Britto, Loïc Bullock...
https://pubmed.ncbi.nlm.nih.gov/29923910