Actively Recruiting
Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Led by University of Trieste · Updated on 2026-05-04
20
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Altitude training has been suggested to be of potential support to improve some chronic clinical conditions, especially metabolic conditions. Normobaric hypoxia represents a promising system to simulate altitude training, and its efficacy and safety have been suggested in different conditions, including diabetes, obesity and hypertension. Metabolic dysfunction-associated steatotic liver disease (MASLD) can characterized by metabolic alterations (including altered body composition, lipid and glycemic profile, etc.), and might benefit from aerobic training performed in simulated altitude training (i.e., normobaric hypoxia). Mild altitude training will be proposed (equal to about 2'500 m, 15% FiO2) and compared to a sham normobaric normoxia condition, during an 8-week 3 or 2 times per week 1-h aerobic training (walking) at 60-65% of maximum heart rate (HRmax). Cardiorespiratory fitness, body composition, and metabolic profile will be investigated.
CONDITIONS
Official Title
Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) for at least 3 years
- Body mass index (BMI) over 26 kg/m2
- Currently sedentary (inactive lifestyle)
You will not qualify if you...
- Cardiovascular, respiratory, or kidney complications
- Hypertension
- Chronic obstructive pulmonary disease (COPD)
- History of acute mountain sickness or altitude-related symptoms
- Females who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Trieste - Exercise Physiology and Kinesiology Lab
Trieste, Trieste, Italy, 34100
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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