Study of 8-Week Normobaric Hypoxic or Normal Oxygen Aerobic Training for Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease MASLD

What this Trial Is About

Researchers are investigating the effects of normobaric hypoxic aerobic training on people with Metabolic Dysfunction-Associated Steatotic Liver Disease MASLD. This condition involves metabolic changes such as altered body composition and blood sugar levels. The study aims to evaluate how aerobic training under simulated altitude conditions compares to normal oxygen conditions in improving metabolic health and fitness. Participants will be randomly assigned to one of two groups one group will perform aerobic training while breathing air with reduced oxygen levels simulating an altitude of about 2,500 meters, and the other group will perform the same training with normal oxygen levels. Training consists of walking on a treadmill for one hour, two to three times per week, at 60-65% of their maximum heart rate, for eight weeks. Throughout the study, participants will undergo assessments of body weight, fat percentage, oxygen uptake, liver health markers, blood fats, inflammation markers, and blood sugar levels both before and after the eight-week training period. The researchers will monitor these outcomes to understand how the different training conditions affect metabolic health and fitness in people with MASLD.

Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)