Evaluating Antimicrobial Photodynamic Therapy with Periodontal Treatment to Reduce Bad Breath in Adults with Type 2 Diabetes
Led by University of Sao Paulo · Updated on 2026-03-16
32
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of periodontal treatment combined with a tongue scraper, compared with the same treatment plus antimicrobial photodynamic therapy aPDT, in reducing bad breath halitosis in people who have periodontal disease and type 2 diabetes. The trial aims to determine if adding aPDT to conventional treatment is more effective for treating halitosis and improving periodontal health. This study is a randomized clinical trial sponsored by the University of Sao Paulo.
Participants will receive one of two treatments scaling and root planing with antimicrobial photodynamic therapy applied to periodontal pockets and the tongue, or scaling and root planing with a tongue scraper only. Treatments will be given once a week for one month. After this active treatment phase, participants will attend maintenance and control visits once a month for up to six months.
During the study, participants will visit the clinic weekly during treatment and monthly during follow-up. Researchers will assess halitosis from enrollment through six months, along with periodontal health measurements such as probing depth and clinical attachment level. These evaluations will help determine the added effects of aPDT compared to conventional treatment. The total participation time covers one month of active treatment plus six months of follow-up.
CONDITIONS
Brief Title
Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus
Research Team
C
Carla A. Damante, PhD
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Patients diagnosed with type 2 diabetes mellitus according to the 2019 WHO criteria
Stage 3 or 4 periodontitis
No periodontal treatment in the previous 12 months
A minimum of 20 remaining teeth
Adults between 18 and 70 years old
You will not qualify if you...
Smokers
Alcohol-dependent individuals
Pregnant or lactating women
Patients with renal disorders
Patients using medications that affect the periodontium
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Treatment
Duration - 6 months
Participants receive periodontal treatment including scaling and root planing. One group also receives antimicrobial photodynamic therapy in periodontal pockets and on the tongue, while the control group receives tongue scraping.
At least 1 treatment visit with follow-up visits during the 6 months
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Assessment of photodynamic therapy with annatto and led for the treatment of halitosis in mouth-breathing children: Randomized controlled clinical trial.
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