Actively Recruiting

Phase Not Applicable
Age: 18Years - 70Years
All Genders
ID07463859

Effects of Periodontal Treatment with Antimicrobial Photodynamic Therapy on Halitosis in Patients with Diabetes Mellitus

Led by University of Sao Paulo · Updated on 2026-03-16

32

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the effectiveness of periodontal treatment combined with a tongue scraper, compared with the same treatment plus antimicrobial photodynamic therapy (aPDT), in reducing bad breath (halitosis) in people who have periodontal disease and type 2 diabetes. The trial aims to determine if adding aPDT to conventional treatment is more effective for treating halitosis and improving periodontal health. This study is a randomized clinical trial sponsored by the University of Sao Paulo. Participants will receive one of two treatments: scaling and root planing with antimicrobial photodynamic therapy applied to periodontal pockets and the tongue, or scaling and root planing with a tongue scraper only. Treatments will be given once a week for one month. After this active treatment phase, participants will attend maintenance and control visits once a month for up to six months. During the study, participants will visit the clinic weekly during treatment and monthly during follow-up. Researchers will assess halitosis from enrollment through six months, along with periodontal health measurements such as probing depth and clinical attachment level. These evaluations will help determine the added effects of aPDT compared to conventional treatment. The total participation time covers one month of active treatment plus six months of follow-up.

CONDITIONS

Brief Title

Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus

Who Can Participate

Age: 18Years - 70Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients diagnosed with type 2 diabetes mellitus according to the 2019 WHO criteria
  • Stage 3 or 4 periodontitis
  • No periodontal treatment in the previous 12 months
  • A minimum of 20 remaining teeth
  • Adults between 18 and 70 years old
Not Eligible

You will not qualify if you...

  • Smokers
  • Alcohol-dependent individuals
  • Pregnant or lactating women
  • Patients with renal disorders
  • Patients using medications that affect the periodontium

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Treatment

Duration - 6 months

Participants receive periodontal treatment including scaling and root planing. One group also receives antimicrobial photodynamic therapy in periodontal pockets and on the tongue, while the control group receives tongue scraping.

At least 1 treatment visit with follow-up visits during the 6 months

Trial Site Locations

Total: 1 location

1

Bauru School of Dentistry

Bauru, São Paulo, Brazil, 17012901

Actively Recruiting

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Research Team

C

Carla A. Damante, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Assessment of photodynamic therapy with annatto and led for the treatment of halitosis in mouth-breathing children: Randomized controlled clinical trial.

Laura Hermida Bruno, Amanda Rafaelly Honório Mandetta, Ana Paula Taboada Sobral...

https://pubmed.ncbi.nlm.nih.gov/39226284

Effect of antimicrobial photodynamic therapy with red led and methylene blue on the reduction of halitosis: controlled microbiological clinical trial.

Ana Carolina Costa da Mota, Marcela Leticia Leal Gonçalves, Anna Carolina Ratto Tempestini Horliana...

https://pubmed.ncbi.nlm.nih.gov/33987732