Comparison of High and Low Molecular Weight Hyaluronic Acid Injections for Treating Temporomandibular Joint Disorders Using Arthrocentesis

What this Trial Is About

Researchers are evaluating the effectiveness of high molecular weight versus low molecular weight hyaluronic acid injections after two-needle arthrocentesis in patients aged 17 to 70 years with painful symptoms and internal derangement of the temporomandibular joint TMJ that has not improved after conservative treatment. The goal is to compare how these injections improve pain, mouth opening, and joint noises such as clicking or cracking. Participants will be divided into two groups one receiving injections of high molecular weight hyaluronic acid and the other receiving low molecular weight hyaluronic acid. The procedure involves inserting two small needles into the TMJ while the patient is asleep sterile saline is pumped into the joint and drained out, followed by injection of the assigned hyaluronic acid product. This randomized study uses a single-blind design to compare the two treatments. During the study, patients will be assessed for improvements in pain severity on a scale of 1 to 10, range of mouth opening measured in millimeters, and the presence or absence of joint noises such as clicking and cracking. The primary outcome is the efficacy of the injections over a 36-month period. Safety and symptom improvements will be monitored through clinical examinations and patient reports throughout the study duration.

EffIcacy Between Arthrocentesis With High Versus Low Molecular Weight Hyaluronic Acid in Treatment of TMJ Disorders