Treatment of Adult Obstructive Sleep Apnea with Positive Airway Pressure: An American Academy of Sleep Medicine Clinical Practice Guideline.
Susheel P Patil, Indu A Ayappa, Sean M Caples...
https://pubmed.ncbi.nlm.nih.gov/30736887Actively Recruiting
Phase Not Applicable
Age: 18Years - 80Years
All Genders
Healthy Volunteers
ID04557293
Effort-based Decision-making as a Possible Predictor of Poor Adherence to CPAP Treatment in Obstructive Sleep Apnea
Led by Istituti Clinici Scientifici Maugeri SpA · Updated on 2025-11-18
64
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
I
Istituti Clinici Scientifici Maugeri SpA
Lead Sponsor
I
Istituto Universitario di Studi Superiori Pavia
Collaborating Sponsor
AI-Summary
What this Trial Is About
Obstructive sleep apnea (OSA) is a common sleep disorder that affects many people and is linked to problems such as memory and mood issues, high blood pressure, diabetes, daytime sleepiness, nighttime urination, and increased heart and metabolic risks. The usual treatment is Continuous Positive Airway Pressure (CPAP), but many patients struggle to use it regularly. This study explores how decision-making related to effort might affect CPAP use in people with OSA, both before and after treatment. Participants with OSA will have their cognitive functions assessed, focusing on effort-based decision-making, memory, executive function, planning, and response inhibition before starting CPAP treatment and again after six months of use. A control group of similar age and education without sleep disorders will also undergo cognitive assessments for comparison. During the study, researchers will evaluate changes in cognitive functions related to CPAP treatment and how these relate to daytime sleepiness and adherence. Participants will be monitored over six months, with cognitive assessments conducted at the start and after treatment. The study aims to better understand factors influencing CPAP adherence and cognitive changes in OSA patients.
CONDITIONS
Brief Title
Effort-based Decision-making and CPAP Adherence
Who Can Participate
Age: 18Years - 80Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Apnea-Hypopnea Index (AHI) of 15 or higher
You will not qualify if you...
- Body Mass Index (BMI) of 35 Kg/m2 or higher
- Mini-Mental State Examination (MMSE) score below 24
- Complex sleep apnea
- Presence of any other sleep disorder
- Psychiatric disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - Initial assessment period
Participants with obstructive sleep apnea receive Continuous Positive Airway Pressure (CPAP) treatment and cognitive assessments are conducted before starting CPAP.
1 baseline visit (in-person)
Implementation
Duration - 6 months of CPAP treatment
Participants continue CPAP treatment and cognitive assessments are repeated after six months of CPAP use.
1 follow-up visit after 6 months (in-person)
Trial Site Locations
Total: 1 location
1
ICS Maugeri Pavia
Pavia, Italy, 27100
Actively Recruiting
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Research Team
N
Nicola Canessa, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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Published Research Related To This Trial
Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment.
Nicola Canessa, Vincenza Castronovo, Stefano F Cappa...
https://pubmed.ncbi.nlm.nih.gov/21037021