Actively Recruiting
Sex Differences in Neurocirculatory Control With Obstructive Sleep Apnea
Led by Mayo Clinic · Updated on 2026-01-07
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how men and women with untreated obstructive sleep apnea (OSA) may differ in how their nervous system controls blood pressure. This observational study aims to understand sex differences in neurocirculatory regulation among adults aged 20 to 70 with OSA. The trial is sponsored by Mayo Clinic and focuses on baseline measurements of blood pressure, arterial stiffness, and endothelial function. Participants will be observed without receiving any study treatments or interventions. The study measures include sympathetic nerve activity parameters such as burst frequency, incidence, amplitude, and total muscle sympathetic nerve activity. There are no specified treatment groups or placebo comparisons since this is an observational study. During the study, participants will undergo assessments to measure blood pressure and vascular function as well as detailed evaluations of nerve activity controlling circulation. These tests occur at baseline to gather initial data. The study will monitor participants for any changes and aims to complete data collection by March 2027. Participants' usual care continues alongside their involvement in this research.
CONDITIONS
Brief Title
A Study of Sex Differences in Neurocirculatory Control
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 20-70 years of age
You will not qualify if you...
- Coronary artery disease
- Heart failure
- Pregnancy
- COPD
- Diabetes
- Chronic kidney disease (CKD)
- Sleep disorders other than obstructive sleep apnea (OSA)
- Shift workers
- Individuals who typically go to sleep after midnight
- Individuals who traveled across 2 time zones within one week of study visits
- Body mass index (BMI) 5.0 kg/m2 or higher
- Use of nicotine-containing products within the two years preceding study visits
- Use of allopurinol, proton pump inhibitors, or other medications/supplements that interfere with outcome measures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline assessments including blood pressure, arterial stiffness, endothelial function, and sympathetic nerve activity measurements.
1 visit (in-person)
Duration - Up to 3 years
Participants are observed to understand neurocirculatory control differences associated with obstructive sleep apnea.
Visits may occur as part of routine care or scheduled assessments
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
J
Joshua Bock, PhD
I
Ian Greenlund, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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