Actively Recruiting
Evaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta Spectrum
Led by University of California, Los Angeles · Updated on 2026-01-16
60
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a topographic classification system for placenta accreta spectrum (PAS) to improve surgical planning and outcomes. This prospective cohort study focuses on the clinical use of an intraoperative staging protocol alongside prenatal ultrasound to better classify PAS and guide surgical decisions. The study aims to validate the classification system by comparing ultrasound findings with intraoperative and postoperative data, while also exploring biomarkers linked to PAS severity. Participants are pregnant individuals at risk for PAS undergoing planned surgical interventions such as total hysterectomy, modified subtotal hysterectomy, or one-step conservative surgery. The study integrates prenatal ultrasound staging with intraoperative classification to inform real-time surgical management. Data collected will include surgical details, photos, videos, blood loss measurements, and pathological examination of tissues. Optional serial blood draws will be stored in a biorepository for biomarker analysis. During the study, participants will undergo ultrasound assessments within 30 days before surgery and intraoperative evaluation during the procedure. Blood loss will be documented throughout surgery, and tissue analysis will occur within two hours post-surgery. Researchers will monitor adverse events for up to 12 months after surgery. The anticipated study duration is approximately 36 to 48 months, covering prenatal assessment, surgery, and follow-up evaluations.
CONDITIONS
Brief Title
Evaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta Spectrum
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant people suspected of having placenta accreta spectrum based on ultrasound findings or clinical risk factors
- Patients undergoing planned surgical intervention for placenta accreta spectrum, including a planned cesarean
- Individuals who provide informed consent to participate in the study
- Patients with at least one prenatal assessment before surgery
- Expected age range: 18-55 years
- Patient has agreed to conservative management approach as part of standard of care if feasible intraoperatively
You will not qualify if you...
- Patients who decline participation or withdraw consent
- Those with contraindications to the planned surgical procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 30 days prior to planned surgery
Participants undergo ultrasound assessments to evaluate placenta accreta spectrum and plan surgical intervention.
1 to 2 visits depending on ultrasound scheduling
Duration - Day of planned surgery
Participants receive planned surgical intervention for placenta accreta spectrum with intraoperative staging and classification guiding surgical decisions.
1 surgical visit (in-person)
Duration - Up to 12 months post surgery
Participants are monitored for clinical outcomes including adverse events and recovery up to 12 months after surgery.
Approximately 6 post-operative visits
Trial Site Locations
Total: 1 location
1
University of California, Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
D
Dana Levin-Lopez, MPH
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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