Actively Recruiting
Beni-Suef University Hospital Simplified Conservative Approach for Managing Placenta Accreta Spectrum: Randomized Controlled Trial
Led by Nesreen Abdel Fattah Abdullah Shehata · Updated on 2024-06-20
172
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two surgical techniques to manage morbidly adherent placenta, a serious pregnancy condition where the placenta attaches too deeply to the uterus. The study aims to compare the effectiveness of modified uterine artery ligation and myometrial compression as conservative treatments to improve patient outcomes while preserving fertility. This approach follows guidelines recommending avoidance of hysterectomy, which can have negative effects on pelvic and physical functions. The study involves two groups of patients with placenta accreta. One group will receive bilateral uterine artery ligations using the O-lreay technique combined with standard conservative methods. The other group will undergo a modified O-lreay technique that includes uterine ligation with compression of the lower uterine segment after placental separation. Both procedures involve careful stitching and avoiding injury to surrounding organs. Participants will be monitored for blood loss six hours after surgery, along with maternal morbidity and mortality within 24 hours postoperatively. The study includes assessments of clinical stability, vaginal bleeding, and fetal condition before enrollment. The total participation period spans from surgery through early postoperative monitoring, with all data collected to evaluate the safety and effectiveness of these conservative surgical measures.
CONDITIONS
Brief Title
Simplified Conservative Measures in Managing Morbidly Adherent Placenta in Beni-Suef University
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Gestational age more than 28 weeks as determined by last menstrual period and ultrasound
- Diagnosis of placenta previa confirmed by ultrasound
- Clinically stable with no or mild vaginal bleeding
- No evidence of fetal compromise
- Patient consent
You will not qualify if you...
- Vaginal bleeding
- Medical disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of delivery and immediate recovery period
Participants undergo surgery involving either the O- lreay technique or the modified O- lreay technique as conservative approaches to manage placenta accreta spectrum, aiming to avoid hysterectomy and preserve fertility.
1 surgical procedure and immediate post-operative hospital stay
Duration - 24 hours postoperatively
Participants are monitored for maternal morbidity and mortality, as well as amount of blood loss within 24 hours postoperatively.
1 to 2 post-operative visits
Trial Site Locations
Total: 1 location
1
Beni-Suef University
Cairo, Egypt
Actively Recruiting
Research Team
H
Hamada Ali, A. professor
N
nesreen shehata, professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here