Actively Recruiting

Age: 6Years - 16Years
All Genders
Healthy Volunteers
NCT06661278

Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias

Led by Royal Brompton & Harefield NHS Foundation Trust · Updated on 2025-05-31

110

Participants Needed

2

Research Sites

41 weeks

Total Duration

On this page

Sponsors

R

Royal Brompton & Harefield NHS Foundation Trust

Lead Sponsor

G

Great Ormond Street Hospital for Children NHS Foundation Trust

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia. The main question it aims to answer is: Does maximum heart rate during controlled exercise tolerance testing accurately reflect maximum heart rate and peak exercise levels during free living daily physical activity in children and adolescents diagnosed with an inherited arrhythmia? Participants will: * Complete routine exercise tolerance testing * Record daily physical activity and exercise over two weeks, while wearing an activity and heart rate monitor and digit diary. * Complete a physical activity questionnaire at the end of two weeks.

CONDITIONS

Official Title

Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias

Who Can Participate

Age: 6Years - 16Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Male and female children aged 6 to 16 years
  • Diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia
  • Treated with beta-blocker and/or sodium channel blockade
  • Able to complete a treadmill exercise tolerance test
  • Healthy siblings of affected children (gene negative) undergoing screening
  • Able to complete a treadmill exercise tolerance test
Not Eligible

You will not qualify if you...

  • Children younger than 6 years
  • Adults aged 17 years and above
  • Unable to run on an exercise treadmill due to physical limitations
  • Unable to speak or understand English due to no translation service
  • Pregnancy

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 2 locations

1

Great Ormond Street Hospital

London, United Kingdom, WC1N 3JH

Actively Recruiting

2

Royal Brompton Hospital

Sutton, United Kingdom, SW36NP

Actively Recruiting

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Research Team

C

Catherine E Renwick

CONTACT

E

Ethaar El-Emire

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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