Study of Immune Cell Activity and Blood Clotting in Patients of All Ages Undergoing Complex Heart Surgery with Cardiopulmonary Bypass

What this Trial Is About

Researchers are studying patients of all ages undergoing complex heart surgeries that use cardiopulmonary bypass CPB to better understand blood clotting problems that can happen during and after surgery. The study focuses on the role of immune cells called monocytes and substances in the blood like GABA and inflammatory cytokines, which may contribute to abnormal clot formation and related complications. This observational research aims to explore these biological factors to improve future care for patients at risk of blood clots during heart surgery. The study uses discarded blood samples taken during routine clinical testing before, during, and after cardiac surgery to analyze monocyte activation and levels of serum GABA and pro-inflammatory cytokines. By collecting data over the course of surgery and recovery, the research team hopes to find links between immune activity and clotting risks. The study does not involve experimental treatments but focuses on detailed laboratory analyses of blood samples. Participants provide blood samples during their surgical care, with no additional interventions beyond routine clinical procedures. Researchers will monitor monocyte activation status and blood markers related to inflammation and clotting for about one year following surgery. The main outcomes measured include monocyte activation, serum GABA, pro-inflammatory cytokines, and clinical thrombosis events. This allows for a comprehensive assessment of factors involved in clotting complications after complex cardiac surgery with CPB.

Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery