Invasive Hemodynamic Cardiopulmonary Exercise Testing for Assessment of Patients With Congenital Heart Disease

What this Trial Is About

Researchers are evaluating the ability to detect blood flow and heart function abnormalities in patients with congenital heart disease using invasive hemodynamic assessments at rest and during exercise. The study aims to compare how well invasive measurements match noninvasive Doppler methods and to see how these measurements relate to disease severity. This research is sponsored by the Mayo Clinic and focuses on improving assessment techniques for congenital heart disease. Participants will undergo a standard cardiac catheterization procedure alongside an invasive cardiopulmonary exercise test during the same procedure. This combined testing will measure heart and blood vessel function at rest and during peak exercise to capture changes in heart muscle stiffness, cardiac output, vascular resistance, and strain on the right ventricle. The intervention involves one study group consisting of patients undergoing clinically indicated cardiac catheterization with the added exercise testing. During the study, participants will be closely monitored through invasive measurements collected during their catheterization and exercise testing. Researchers will evaluate changes from rest to peak exercise in multiple heart function indicators, including left and right ventricular output, systemic and pulmonary vascular resistance, and ventricular strain. The study will last until December 2026, and the data collected will help understand heart function during exercise in congenital heart disease patients.

A Study of Hemodynamic Cardiopulmonary Exercise for CHD