Assessment of Exercise Capacity in Heart Failure Patients with Preserved Ejection Fraction Based on Coronary Microvascular Function and Body Composition

What this Trial Is About

Researchers are investigating how coronary microvascular function and body composition relate to exercise capacity in patients who have heart failure with preserved ejection fraction HFpEF. The study focuses on patients experiencing chest pain or ischemic symptoms but with less than 50% coronary artery blockage and a preserved heart pumping function of 50% or more. The goal is to better understand the link between coronary blood flow, body composition, and cardiopulmonary exercise capacity. All participants will undergo several tests including adenosine stress echocardiography to evaluate coronary artery blood flow using Doppler ultrasound, body composition analysis using impedance measurements across different body parts, and a cardiopulmonary exercise test CPET to measure maximal oxygen consumption VO2 max. Additionally, left ventricular end-diastolic pressure will be assessed during coronary angiography. These tests will provide comprehensive data on heart function and body composition. During the study, participants will have body composition analysis, stress echocardiography, and exercise testing performed, along with coronary angiography to measure heart pressures. Researchers will analyze the correlation between coronary flow reserve and body composition with exercise capacity, measured up to 14 days after enrollment. This study does not involve treatment but focuses on diagnostic and functional assessments to understand exercise capacity in this patient group.

Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition