Actively Recruiting
Exercise Training and Fat Metabolism in Postmenopausal Women
Led by Florida State University · Updated on 2026-04-13
120
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
Sponsors
F
Florida State University
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
CONDITIONS
Official Title
Exercise Training and Fat Metabolism in Postmenopausal Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women
- Postmenopausal aged 50 to 75 years
- Obese with BMI between 30 and 50 kg/m2
- Prediabetes defined by HbA1c 5.7 - 6.4%, fasting blood glucose 100 to 125 mg/dL, or 2-hour OGTT blood glucose 140 to 199 mg/dL
- Sedentary lifestyle, not performing purposeful exercise more than 20 minutes twice a week
- Non-smokers
- No hormone replacement therapy for at least the past two years
You will not qualify if you...
- Engaging in purposeful resistance or endurance training more than 20 minutes per day, more than 2 days per week
- Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
- Diagnosis of type 1 or type 2 diabetes
- Medical problems that contraindicate exercise, such as chronic infections
- History or current presentation of cancer, cardiovascular, or respiratory disease
- Uncontrolled thyroid dysfunction, liver or kidney dysfunction
- Taking medications affecting lipid metabolism
- Musculoskeletal disease or injury preventing resistance or endurance training
- Smokers
- Diagnosed eating disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Florida State University
Tallahassee, Florida, United States, 32306
Actively Recruiting
Research Team
R
Robert C Hickner, PhD
CONTACT
M
Michael J Ormsbee, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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