Actively Recruiting
Exploration of Potential Biomarkers of Polyphenol Intake From a Supplement Derived From Artichoke By-products Rich in Hydroxycinnamic Acids
Led by Iziar Amaia Ludwig Sanz Orrio · Updated on 2026-06-03
16
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
I
Iziar Amaia Ludwig Sanz Orrio
Lead Sponsor
M
Ministerio de Ciencia e Innovación, Spain
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how polyphenols from artichoke by-products are absorbed, distributed, metabolized, and excreted in healthy adults. This research aims to identify active compounds and their metabolites in the body after taking a supplement rich in hydroxycinnamic acids (HCAs), helping to understand differences in metabolic responses among individuals. Participants will follow a low-polyphenol diet for 48 hours before and after taking the supplement to reduce background intake. On the study day, volunteers will consume six capsules containing dehydrated artichoke powder providing 197.4 mg of HCAs after fasting overnight. Blood samples will be collected at baseline and multiple times up to 48 hours after intake, while urine samples will be gathered over specified intervals before and after taking the supplement. During the study, researchers will analyze blood and urine samples using advanced laboratory techniques to detect and measure HCAs and their metabolites. Participants will be monitored for changes in these compounds over time. The study focuses on understanding the bioavailability of these compounds through detailed sample collection and analysis over a total period of 96 hours including dietary restrictions and sample collection phases.
CONDITIONS
Brief Title
Exploration of Potential Biomarkers of Polyphenol Intake From Artichoke By-product Supplements
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women between 18 and 75 years of age.
- Normal-weight volunteers with a BMI of 18.5-24.9 kg/m².
- Ability to understand and willingness to sign the informed consent form.
- Willingness to comply with all study procedures and requirements.
You will not qualify if you...
- Presence of chronic gastrointestinal pathology.
- Lactating or pregnant women, or those planning to become pregnant.
- Antibiotic use within 3 months prior to the study.
- Current use of supplements (plant-derived, fiber, or probiotics) unless discontinued during the study and with a 14-day washout before baseline.
- Alcohol intake greater than 80 grams per day.
- Allergy or intolerance to artichoke.
- Treatment with anticoagulants, immunosuppressants, or cytotoxic agents.
- Renal or hepatic failure.
- Immunodeficiency or HIV positive status.
- Any type of cancer or cancer treatment within the past 5 years.
- Weight loss greater than 5% in the 6 months before the trial.
- Lack of time or geographic availability for study visits.
- Failure to sign the informed consent form.
- Difficulty undergoing blood collection.
- Blood donation within 14 days prior to baseline visit.
- Difficulty swallowing capsules or similar forms of medication.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 days of diet plus 48 hours post-intake
Participants follow a low-polyphenol diet for two days before and during the 48 hours of the dietary intervention. After fasting overnight, participants consume a single dose of 6 capsules of dehydrated artichoke by-product with water.
1 baseline visit and multiple sample collections over 48 hours
Duration - 48 hours
Participants provide blood and urine samples at specified intervals up to 48 hours after intake to assess biomarkers of polyphenol intake.
Blood samples at baseline, 1, 2, 4, 7, 24, and 48 hours; urine samples collected at 24 hours pre-intake, and multiple intervals up to 48 hours post-intake
Trial Site Locations
Total: 1 location
1
Universidad de Navarra
Pamplona, Navarre, Spain, 31008
Actively Recruiting
Research Team
I
Iziar A Ludwig, PhD
I
Idoia Ibero, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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